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Exploring toxicological interactions in a changing sea: the case of the alkaloi...

Russo, Tania; Coppola, Francesca; Paris, Debora; De Marchi, Lucia; Meucci, Valentina; Motta, Andrea; Carbone, Marianna; Di Cosmo, Anna

The bisindolic alkaloid caulerpin (CAU) is a bioactive compound isolated from green algae of the genus Caulerpa that are highly invasive in the Mediterranean Sea. On the other side, the purine alkaloid caffeine (CAF) is one of the most globally consumed psychoactive substances and a widespread anthropogenic water pollutant. Both compounds display a large panel of biological properties and are well known to accu...


An alien metabolite vs. a synthetic chemical hazard: an ecotoxicological compar...

Russo, Tania; Coppola, Francesca; Leite, Carla; Carbone, Marianna; Paris, Debora; Motta, Andrea; Di Cosmo, Anna; Soares, Amadeu M. V. M.; Mollo, Ernesto

Bioactive natural products from marine invasive species may dramatically impact native communities, while many synthetic pharmaceutical drugs are released into the marine environment and have long-lasting harmful effects on aquatic life. Sometimes, metabolites from alien species and synthetic compounds share similar mechanisms of action, suggesting comparable ecotoxicological impacts. This applies to the alkalo...


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