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Seroconversion Rate Following HBV Vaccination in Clinical Practice: The Role of...

Faustino, P; Coutinho, M; Leitão, L; Capela, C; Brum, M; Parra, J; Sequeira, J; Barros, A; Araújo, C; Sousa, A; Ladeira, F

HBV screening and immunization is recommended in all MS patients and is mandatory before the start of some DMT. However, studies evaluating the immune response to HBV vaccine in MS patients are scarce. We aimed to evaluate the seroprotection rate following HBV immunization in MS patients and to assess if older age and DMT-treatment influenced seroprotection. We conducted a cohort study between 2016 and 2020 and...


Real-Word Effectiveness and Safety of Dimethyl Fumarate in a Multiple Sclerosis...

Barros, A; Sequeira, J; Sousa, A; Parra, J; Brum, M; Pedrosa, R; Capela, C

Objectives: The aim of this study was to evaluate postmarketing dimethyl fumarate (DMF) safety and effectiveness in a real-world population with relapsing-remitting multiple sclerosis (RRMS). Methods: This was a retrospective, single-center study with RRMS patients treated with DMF. Demographic, clinical, and imagiological characteristics were analyzed, including annualized relapse rate (ARR), Expanded Disabili...


Aphasia Rapid Test: Translation, Adaptation and Validation Studies for the Port...

Tábuas-Pereira, M; Freitas, S; Beato-Coelho, J; Ribeiro, JA; Parra, J; Martins, C; Silva, M; Matos, MA; Nogueira, AR; Silva, F; Sargento-Freitas, J

Classical aphasia evaluation scales are too long to use in the context of acute stroke or as a monitoring tool. The Aphasia Rapid Test is a 26-point scale developed as a bedside assessment to rate aphasia severity in acute stroke patients in less than 3 minutes. We aimed to adapt and validate this scale for European Portuguese.


Dyschromatopsia in Multiple Sclerosis Patients: A Marker of Subclinical Involve...

Felgueiras, H; Parra, J; Cruz, S; Pereira, P; Santos, A; Rua, A; Meira, D; Fonseca, P; Pedrosa, C; Cardoso, J; Almeida, C; Araújo, M; Santos, E

BACKGROUND: In multiple sclerosis (MS), even in the absence of a clinical episode of optic neuritis (ON), the optic nerve and retinal nerve fiber layer (RNFL) may be damaged leading to dyschromatopsia. Subclinical dyschromatopsia has been described in MS associated with lower motor and cognitive performances. OBJECTIVES: To set the prevalence of dyschromatopsia in eyes of MS patients without a history of ON, to...


Extensive intracranial involvement with multiple dissections in a case of giant...

Parra, J; Domingues, J; Sargento-Freitas, J; Santana, I

A 56-year-old man presented with weight loss, articular pain and minor neurological symptoms progressing over 1 month. Neurosonological evaluation suggested occlusion in intracranial segments of the left vertebral artery (VA) and of both internal carotid arteries (ICA) and hypoechoic halo sign in both superficial temporal arteries. The diagnosis of giant cell arteritis was supported by inflammatory markers and ...


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