8 documents found, page 1 of 1
Development and Characterization of Biointeractive Gelatin Wound Dressing Based...
Nascimento, Marismar F. do; Cardoso, Juliana C.; Santos, Tarsizio S.; Tavares, Lívia A.; Pashirova, Tatiana N.; Severino, Patrícia; Souto, Eliana B.Punica granatum Linn (pomegranate) extracts have been proposed for wound healing due to their antimicrobial, antioxidant, and anti-inflammatory properties. In this work, we designed biointeractive membranes that contain standard extracts of P. granatum for the purpose of wound healing. The used standard extract contained 32.24 mg/g of gallic acid and 41.67 mg/g of ellagic acid, and it showed high antioxidant ac...
Polymer nanogels: Fabrication, structural behavior, and biological applications
Pashirova, Tatiana N.; Fernandes, Ana R.; Sanchez-Lopez, Elena; Garcia, Maria L.; Silva, Amélia M.; Zakharova, Lucia Ya.; Souto, Eliana B.Nanogels are defined as colloids-based hydrogels, representing a three-dimensional network of a hydrophilic polymer in which drugs can be entrapped. Nanogels are soft, conformable, highly permeable, and stimuli-responsive networks, which can be surface-modified with functional groups aiming at conjugation with small and large macromolecules. Nanogels also offer several advantages attributed to their capacity to...
Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles f...
Buzyurova, Daina N.; Pashirova, Tatiana N.; Zueva, Irina V.; Burilova, Evgenia A.; Shaihutdinova, Zukhra M.; Rizvanov, Ildar Kh.; Babaev, Vasily M.The nanotechnological approach is an innovative strategy of high potential to achieve reactivation of organophosphorus-inhibited acetylcholinesterase in central nervous system. It was previously shown that pralidoxime chloride-loaded solid lipid nanoparticles (2-PAM-SLNs) are able to protect the brain against pesticide (paraoxon) central toxicity. In the present work, we increased brain AChE reactivation effica...
Development and characterization of biointeractive gelatin wound dressing based...
Nascimento, Marismar F. do; Cardoso, Juliana C.; Santos, Tarsizio S.; Tavares, Lívia A.; Pashirova, Tatiana N.; Severino, Patricia; Souto, Eliana B.Punica granatum Linn (pomegranate) extracts have been proposed for wound healing due to their antimicrobial, antioxidant, and anti-inflammatory properties. In this work, we designed biointeractive membranes that contain standard extracts of P. granatum for the purpose of wound healing. The used standard extract contained 32.24 mg/g of gallic acid and 41.67 mg/g of ellagic acid, and it showed high antioxidant ac...
Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-su...
Pashirova, Tatiana N.; Burilova, Evgeniya A.; Lukashenko, Svetlana S.; Gaysin, Nail K.; Gnezdilov, Oleg I.; Sapunova, Anastasia S.; Fernandes, Ana R.Self-assembly and solubilization properties of amphiphilic mono- and bisquaternized derivatives of 1,4-diazabicyclo[2.2.2]octane (mono-CS-n and di-CS-n, where CS cationic surfactant, n=12, 14, 16, 18) was investigated by nuclear magnetic resonance with magnetic field pulse gradient. The influence of Dabco-surfactant structure (head group and length of alkyl chains) on critical micelle concentration and aggregat...
Cationic surfactants: self-assembly, structure-activity correlation and their b...
Zakharova, Lucia Ya.; Pashirova, Tatiana N.; Doktorovova, Slavomira; Fernandes, Ana R.; Sanchez-Lopez, Elena; Silva, Amélia M.; Souto, Selma B.The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of n...
Soft cationic nanoparticles for drug delivery: production and cytotoxicity of s...
Silva, Amélia M.; Martins-Gomes, Carlos; Coutinho, Tiago E.; Fangueiro, Joana F.; Sanchez-Lopez, Elena; Pashirova, Tatiana N.; Andreani, TatianaThe surface properties of nanoparticles have decisive influence on their interaction with biological barriers (i.e., living cells), being the concentration and type of surfactant factors to have into account. As a result of different molecular structure, charge, and degree of lipophilicity, different surfactants may interact differently with the cell membrane exhibiting different degrees of cytotoxicity. In thi...
Nanoparticle delivery systems in the treatment of diabetes complications
Souto, Eliana B.; Souto, Selma B.; Campos, Joana R.; Severino, Patricia; Pashirova, Tatiana N.; Zakharova, Lucia Y.; Silva, Amélia M.Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line treatment. This administration route is however associated with limited patients compliance, due to the risk of pain, discomfort and local infection. Nanoparticles have been proposed as insulin carriers to make possible the administra...