6 documents found, page 1 of 1
Identification of 170 new long noncoding RNAs in Schistosoma mansoni.
Oliveira, Victor Fernandes de; Moraes, Lauro Ângelo Gonçalves de; Mota, Ester Alves; Passos, Liana Konovaloff Jannotti; Coelho, Paulo Marcos ZechLong noncoding RNAs (lncRNAs) are transcripts generally longer than 200 nucleotides with no or poor protein coding potential, and most of their functions are also poorly characterized. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes such as organism development or cancer progression. Little, however, is known about their effects in helmi...
Transcriptional profile and structural conservation of SUMO-Specific proteases ...
Pereira, Roberta Verciano; Cabral, Fernanda Janku; Gomes, Matheus de Souza; Passos, Liana Konovaloff Jannotti; Borges, William de CastroSmall ubiquitin-related modifier (SUMO) is involved in numerous cellular processes including protein localization, transcription, and cell cycle control. SUMOylation is a dynamic process, catalyzed by three SUMO-specific enzymes and reversed by Sentrin/SUMO-specific proteases (SENPs). Here we report the characterization of these proteases in Schistosoma mansoni. Using in silico analysis, we identified two SENPs...
Conservation and developmental expression of ubiquitin isopeptidases in Schisto...
Pereira, Roberta Verciano; Vieira, Helaine Graziele Santos; Oliveira, Victor Fernandes de; Gomes, Matheus de Souza; Passos, Liana Konovaloff JannottiSeveral genes related to the ubiquitin (Ub)-proteasome pathway, including those coding for proteasome subunits and conjugation enzymes, are differentially expressed during the Schistosoma mansoni life cycle. Although deubiq¬uitinating enzymes have been reported to be negative regulators of protein ubiquitination and shown to play an im¬portant role in Ub-dependent processes, little is known about their role in ...
NEDD8 conjugation in Schistosoma mansoni : genome analysis and expression profi...
Pereira, Roberta Verciano; Gomes, Matheus de Souza; Olmo, Roenick Proveti; Sousa, Daniel M.; Passos, Liana Konovaloff Jannotti; Babá, Élio HideoNEDD8 is an ubiquitin-like molecule that covalently binds to target proteins through an enzymatic cascade analogous to ubiquitylation. This modifier is known to bind to p53 and p73, as well as all Cullin family proteins, which are essential components of Skp1/Cul-1/F-box protein (SCF)-like Ub ligase complexes. Here, we focused on a genomic analysis of the genes involved in the NEDD8 conjugation pathway in Schis...
Preliminary analysis of miRNA pathway in Schistosoma mansoni.
Gomes, Matheus de Souza; Cabral, Fernanda Janku; Passos, Liana Konovaloff Jannotti; Carvalho, Omar; Rodrigues, Vanderlei; Babá, Élio HideoRNA silencing refers to a series of nuclear and cytoplasmatic processes involved in the post-transcriptional regulation of gene expression or post-transcriptional gene silencing (PTGS), either by sequence-specific mRNA degradation or by translational arrest. The best characterized small RNAs are microRNAs (miRNAs), which predominantly perform gene silencing through post-transcriptional mechanisms. In this work ...
Characterisation of major vault protein during the life cycle of the human para...
Reis, Eneida Virgínia; Pereira, Roberta Verciano; Gomes, Matheus de Souza; Passos, Liana Konovaloff Jannotti; Babá, Élio HideoVaults are ribonucleoproteins (13MDa) highly conserved among lower and higher eukaryotes. Their association produces a complex composed of three proteins named Major Vault Protein (MVP), vault (PolyADP-ribose) polymerase (VPARP) and Telomerase-associated protein (TEP1), plus a small untranslated RNA. The exact function of this complex is unknown, although the biological role of vaults has been associated with m...