Encontrados 2 documentos, a visualizar página 1 de 1
CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukem...
Rodrigues, Cristiana; Laranjeira, Paula; Pinho, A. C. O.; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana Catarina; Simões, Ana TeresaIntroduction: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer. Methods: Here, we quantified and phenotypically characterized CD20...
Optimization of a hybrid bacterial/Arabidopsis thaliana fatty acid synthase sys...
Pozdniakova, T. A.; Cruz, João P.; Silva, Paulo César; Azevedo, Flávio; Parpot, Pier; Domingues, Maria Rosario; Carlquist, Magnus; Johansson, BjörnFatty acids are produced by eukaryotes like baker’s yeast Saccharomyces cerevisiae mainly using a large multifunctional type I fatty acid synthase (FASI) where seven catalytic steps and a carrier domain are shared between one or two protein subunits. While this system may offer efficiency in catalysis, only a narrow range of fatty acids are produced. Prokaryotes, chloroplasts and mitochondria rely instead on a ...