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Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in P...

Sandrim,Valeria Cristina; Luizon,Marcelo Rizzatti; Pilan,Eliane; Caldeira-Dias,Mayara; Coeli-Lacchini,Fernanda Borchers; Kors,Georgia; Berndt,Iuly

Abstract Objective We examined the interaction of polymorphisms in the genes heme oxygenase- 1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA...

Date: 2020   |   Origin: Oasisbr
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