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Aspirin but not statins is inversely related to gastric cancer with a duration–...

Pastorino, R; Pires Marafon, D; Sassano, M; Hoxhaj, I; Pelucchi, C; Liao, LM; Rabkin, CS; Sinha, R; Lunet, N; Morais, S; Zaridze, D; Maximovich, D

Background: Aspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC. Methods: A pooled analysis of seven case-control studies within the Stomach Cancer Pooling Project, including 3220 cases ...


Intake of Proton-Pump Inhibitors and Gastric Cancer within the Stomach Cancer P...

Sassano, M; Mariani, M; Pelucchi, C; Lunet, N; Morais, S; Martín, V; Moreno, V; Curado, MP; Dias-Neto, E; Leja, M; Gasenko, E; La Vecchia, C; Boccia, S

Background: A potential association between proton-pump inhibitors (PPI) and gastric cancer remains undefined. Thus, we aimed to evaluate such association within the Stomach cancer Methods: Data from five case-control studies of the StoP Project were included (1,889 cases and 6,517 controls). We assessed the impact of different exposure definitions, specifically any reported use of PPIs and exposure definitions...


Chronic metformin intake and gastric cancer: A pooled analysis within the Stoma...

Sassano, M; Mariani, M; Pelucchi, C; Vicente, M; Pinto-Carbó, M; Lunet, N; Morais, S; La Vecchia, C; Pastorino, R; Boccia, S

Introduction: The association between chronic use of metformin and risk of gastric cancer (GC) has been investigated with contradicting results. We aimed to study the association between chronic use of metformin and GC by using data from the Stomach cancer Pooling (StoP) Project, an epidemiological consortium of case-control studies on GC. Methods: Data from three studies of the StoP Project with available info...


The Association between Peptic Ulcer Disease and Gastric Cancer: Results from t...

Paragomi, P; Dabo, B; Pelucchi, C; Bonzi, R; Bako, AT; Sanusi, NM; Nguyen, QH; Zhang, Z-F; Palli, D; Ferraroni, M; Vu, KT; Yu, G-P; Turati, F

Background. Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach c...


Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Poo...

Morais, S; Costa, A; Albuquerque, G; Araújo, N; Pelucchi, C; Rabkin, CS; Liao, LM; Sinha, R; Zhang, Z-F; Hu, J; Johnson, KC; Palli, D; Ferraroni, M

Purpose: Previous studies show that consuming foods preserved by salting increases the risk of gastric cancer, while results on the association between total salt or added salt and gastric cancer are less consistent and vary with the exposure considered. This study aimed to quantify the association between dietary salt exposure and gastric cancer, using an individual participant data meta-analysis of studies pa...


The association between diabetes and gastric cancer: results from the Stomach C...

Dabo, B; Pelucchi, C; Rota, M; Jain, H; Bertuccio, P; Bonzi, R; Palli, D; Ferraroni, M; Zhang, Z-F; Sanchez-Anguiano, A; Thi-Hai, Pham, Y

Background Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. Objective To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of mor...


Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach C...

Vitelli-Storelli, F; Rubín-García, M; Pelucchi, C; Benavente, Y; Bonzi, R; Rota, M; Palli, D; Ferraroni, M; Lunet, N; Morais, S; Ye, W; Plymoth, A

Although there is a clear relationship between family history (FH) and the risk of gastric cancer (GC), quantification is still needed in relation to different histological types and anatomical sites, and in strata of covariates. The objective was to analyze the risk of GC according to first-degree FH in a uniquely large epidemiological consortium of GC. This investigation includes 5946 cases and 12,776 control...


Alcohol intake and gastric cancer: Meta-analyses of published data versus indiv...

Ferro, A; Morais, S; Rota, M; Pelucchi, C; Bertuccio, P; Bonzi, R; Galeone, C; Zhang, ZF; Matsuo, K; Ito, H; Hu, J; Johnson, KC; Yu, GP; Palli, D

Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods: We compared ...


Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project

Praud, D; Rota, M; Pelucchi, C; Bertuccio, P; Rosso, T; Galeone, C; Zhang, ZF; Matsuo, K; Ito, H; Hu, JF; Johnson, KC; Yu, GP; Palli, D; Ferraroni, M

Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the Stomach cancer Pooling (StoP) Project', including 10290 cases and 26145 controls. We estimated summary odds ratios (ORs) and the correspon...


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