7 documents found, page 1 of 1
Interleukin-8 and Interleukin-6 are biomarkers of poor prognosis in Esophageal ...
Pastrez, Paula Roberta Aguiar; Barbosa, Ana Margarida; Mariano, Vânia Sammartino; Causin, Rhafaela Lima; Castro, António G.; Torrado, EgídioEsophageal squamous cell carcinoma (ESCC) is a common type of cancer characterized by fast progression and high mortality rates, which generally implies a poor prognosis at time of diagnosis. Intricate interaction networks of cytokines produced by resident and inflammatory cells in the tumor microenvironment play crucial roles in ESCC development and metastasis, thus influencing therapy efficiency. As such, cyt...
Human papillomavirus is not associated to non-small cell lung cancer: data from...
Silva, Estela Maria; Mariano, Vânia Sammartino; Pastrez, Paula Roberta Aguiar; Pinto, Miguel Cordoba; Nunes, Emily Montosa; Sichero, LauraBackground: The pathogenesis of lung cancer is triggered by a combination of genetic and environmental factors, being the tobacco smoke the most important risk factor. Nevertheless, the incidence of lung cancer in non-smokers is gradually increasing, which demands the search for different other etiological factors such as occupational exposure, previous lung disease, diet among others. In the early 80's a theor...
Prevalence of high risk HPV DNA in esophagus is high in Brazil but not related ...
Costa, Allini Mafra da; Fregnani, José Humberto Tavares Guerreiro; Pastrez, Paula Roberta Aguiar; Mariano, Vânia SammartinoThe first publication that associated Human Papillomavirus (HPV) infection and esophageal cancer was published in 1982. However, data are still contradictory and require further investigation. The aim of this study was to identify high risk HPV DNA in esophageal tissue of patients with and without esophageal squamous cell carcinoma (ESCC) and correlate HPV presence with classical risk factors. METHODS: Invited ...
The relation of HPV infection and expression of p53 and p16 proteins in esophag...
Pastrez, Paula Roberta Aguiar; Mariano, Vânia Sammartino; Costa, Allini Mafra da; Silva, Estela Maria; Scapulatempo-Neto, CristovamGOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53 protein levels were assessed by immunohistochemistry (IHC). RESULTS: High-risk HPV (hr-HPV) wa...
Lung cancer samples preserved in liquid medium: One step beyond cytology
Mariano, Vânia Sammartino; Leal, Letícia Ferro; Pastrez, Paula Roberta Aguiar; Silva, Estela Maria; Reis, R. M.; Longatto, AdhemarLung cancer is one of the most common cancer types in men and women worldwide with a high mortality rate. World Health Organization (WHO) classification has accepted biopsy as the primary sample for lung cancer diagnosis, pathological classification and molecular testing for management of patients, yet, the use of alternative sampling procedures is highly encouraged. Bronchial cytological samples require a less...
High systemic IL-6 is associated with worse prognosis in patients with non-smal...
Silva, Estela Maria; Mariano, Vânia Sammartino; Pastrez, Paula Roberta Aguiar; Pinto, Miguel Cordoba; Castro, António G.; Syrjanen, Kari JuhaniCharacteristic cytokine patterns have been described in different cancer patients and they are related to their diagnosis, prognosis, prediction of treatment responses and survival. A panel of cytokines was evaluated in the plasma of non-small cell lung cancer (NSCLC) patients and healthy controls to investigate their profile and relationship with clinical characteristics and overall survival. The case-controll...
HPV infection and p53 and p16 expression in esophageal cancer: are they prognos...
Costa, Allini Mafra da; Fregnani, José Humberto Tavares Guerreiro; Pastrez, Paula Roberta Aguiar; Mariano, Vânia Sammartino; Silva, Estela MariaBackground: Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignant tumor. Currently, Human papillomavirus (HPV) is suggested as a potential risk factor for esophageal cancer (EC) in addition to the classic risk factors, alcohol and tobacco, but this hypothesis still remains contradictory. We sought to investigate wether HPV and well-known biomarkers (p16 and p53) and patient-related factors that...