3 documents found, page 1 of 1
Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines W...
Nunes, M; Silva, PMA; Coelho, R; Pinto, C; Resende, A; Bousbaa, H; Almeida, GM; Ricardo, SDebulking surgery followed by chemotherapy are the standard of care for high-grade serous carcinoma. After an initial good response to treatment, the majority of patients relapse with a chemoresistant profile, leading to a poor overall survival. Chemotherapy regimens used in high-grade serous carcinomas are based in a combination of classical chemotherapeutic drugs, namely, Carboplatin and Paclitaxel. The mecha...
Tetracyclic thioxanthene derivatives: Studies on fluorescence and antitumor act...
Durães, F; Silva, PMA; Novais, P; Amorim, I; Gales, L; Esteves, CIC; Guieu, S; Bousbaa, H; Pinto, M; Sousa, EThioxanthones are bioisosteres of the naturally occurring xanthones. They have been described for multiple activities, including antitumor. As such, the synthesis of a library of thioxanthones was pursued, but unexpectedly, four tetracyclic thioxanthenes with a quinazoline– chromene scaffold were obtained. These compounds were studied for their human tumor cell growth inhibition activity, in the cell lines A375...
Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and ...
Henriques, AC; Silva, PMA; Sarmento, B; Bousbaa, HAntimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly checkpoint (SAC), leading to cell death. However, drug-treated cancer cells can escape death by undergoing mitotic slippage, due to premature mitotic exit. Therefore, overcoming slippage issue is a promising chemotherapeutic strategy to improve the effectiveness of antimitotics. Here, we antagonized SAC silencing by kno...