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Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...

Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério César de Almeida; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.

Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...


Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associa...

Coelho, Margarida; Patarrão, Rita S.; Sousa-Lima, Inês; Ribeiro, Rogério T.; Meneses, Maria João; Andrade, Rita; Mendes, Vera M.; Manadas, Bruno

Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC-MS/MS. NAFLD was characterized by the fatty liver index (...


How Inflammation Impinges on NAFLD: A Role for Kupffer Cells

Duarte, Nádia; Coelho, Inês C.; Patarrão, Rita S.; Almeida, Joana I.; Penha-Gonçalves, Carlos; Macedo, M. Paula

Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the ...


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