5 documents found, page 1 of 1
Predictive Factors for PCR and Relapse Following Neoadjuvant Dual HER2-Blockade...
Luz, Paulo; Lopes-Brás, Raquel; Pinho, Inês Soares; Patel, Vanessa; Esperança-Martins, Miguel; Gonçalves, Lisa; Gonçalves, Joana; Freitas, RitaPurpose: Neoadjuvant systemic therapy with dual HER2-blockade, trastuzumab and pertuzumab, combined with chemotherapy has become a standard approach in patients with HER2-positive (HER2+) breast cancer (BC). However, the variability in treatment outcomes, such as pathological complete response (pCR) or relapse rates, underscores the need to identify predictive factors to optimize therapeutic strategies. This st...
Retro tIming: A multicentric retrospective analysis of immunotherapy timing in ...
Gonçalves, Lisa; Goncalves, Duarte; Casanelles, Teresa Esteban; Guerra, Laura Pratas; Menezes, Maria B.; Branco, Vanessa Duarte; Luís, Joana AlvesImmune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are now the standard of care in the treatment of metastatic melanoma (mM). The interplay between cancer cells and tumor microenvironment cells (e.g. immune cells) impacts cancer cell survival, local invasion, and metastatic dissemination. Chrono-immunotherapy is an emergin...
Immunotherapy around the clock: impact of infusion timing on stage IV melanoma ...
Gonçalves, Lisa; Gonçalves, Duarte; Esteban-Casanelles, Teresa; Barroso, Tiago; Soares De Pinho, Inês; Lopes Brás, Raquel; Esperança Martins, MiguelAlthough the impact of circadian timing on immunotherapy has yet to be integrated into clinical practice, chronoimmunotherapy is an emerging and promising field as circadian oscillations are observed in immune cell numbers as well as the expression of immunotherapy targets, e.g., programmed cell death protein-1 and its ligand programmed death ligand 1. Concurrent retrospective studies suggest that morning infus...
Anthracyclines versus no anthracyclines in the neoadjuvant strategy for HER2+ b...
Pinho, Inês Soares de; Luz, Paulo; Alves, Lucy; Brás, Raquel Lopes; Patel, Vanessa; Martins, Miguel Esperança; Gonçalves, Lisa; Freitas, RitasDeescalation strategies omitting anthracyclines (AC) have been explored in early human epidermal growth factor receptor 2-positive breast cancer (HER2+ EBC), showing similar efcacy regarding pathological complete response (pCR) and long-term outcomes as AC-containing regimens. The standard treatment for this tumor subtype is based on chemotherapy and dual HER2 blockade with trastuzumab and pertuzumab, with AC-c...
Farinha de casca de cajá-manga e elaboração de pão: avaliação dos compostos fen...
Heidmann, Paola Maria; Patel, VanessaOs resíduos de alimentos gerados no país causa grande impacto ao meio ambiente e na sociedade. As perdas são observadas em toda a cadeia produtiva o que promove a necessidade de aproveitamento desses resíduos em novos produtos alimentícios. A fruta cajá-manga (Spondias cytherea Sonn) pertence a família das Anacardiáceas sendo encontrada nas regiões norte e nordeste do Brasil. A fruta apresenta bons atributos pa...