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Analysis of shared heritability in common disorders of the brain

Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...


Perfectionism in obsessive-compulsive and eating disorders

Maia, Berta R.; Soares, Maria J.; Gomes, Ana; Marques, Mariana; Pereira, Ana Telma; Cabral, Ana Sofia; Valente, José; Bos, Sandra C.; Pato, Michele

Objective: The main aims of this article are twofold. First, to assess perfectionism dimensions in obsessive-compulsive disorder and eating disorders in comparison with psychiatric control (depression/anxiety) and non-clinical control groups. Second, to examine if perfectionism is specifically related to these different clinical conditions. Method: Thirty-nine outpatients with obsessive-compulsive disorder, 24 ...


Perfectionism and eating attitudes in Portuguese university students

Macedo, António; Soares, Maria João; Azevedo, Maria Helena; Gomes, Ana; Pereira, Ana Telma; Maia, Berta; Pato, Michele

The main objective was to explore which are the dimensions of perfectionism that are linked to disordered eating behaviour (EB) in a large non-clinical sample of both genders.One thousand one hundred and sixty-three undergraduate students of the University of Coimbra completed the Portuguese versions of the multidimensional perfectionism scale (MPS) and the eating attitudes test (EAT-40).In both genders, the MP...


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