8 documents found, page 1 of 1
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
Dioli, Chrysoula; Patrício, P.; Trindade, R.; Pinto, L. G.; Silva, J. M.; Morais, M.; Ferreiro, E.; Borges, S.; Mateus-Pinheiro, A.; Rodrigues, A. J.Stress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal f...
Modulation of the mesenchymal stem cell secretome using computer-controlled bio...
Teixeira, Fábio Gabriel Rodrigues; Panchalingam, Krishna M.; Silva, Rita Catarina Assunção Ribeiro; Serra, Sofia CravinoIn recent years it has been shown that the therapeutic benefits of human mesenchymal stem/ stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly attributed to their secretome. The implementation of computer-controlled suspension bioreactors has shown to be a viable route for the expansion of these cells to large numbers. As hMSCs actively respond to their culture environment, there is the hypothe...
Differential and converging molecular mechanisms of antidepressants' action in ...
Patrício, P.; Pinheiro, António Mateus; Irmler, Martin; Alves, Nuno D.; Santos, Ana R. Machado; Morais, Mónica; Silva-Correia, JoanaMajor depression is a highly prevalent, multidimensional disorder. Although several classes of antidepressants (ADs) are currently available, treatment efficacy is limited, and relapse rates are high; thus, there is a need to find better therapeutic strategies. Neuroplastic changes in brain regions such as the hippocampal dentate gyrus (DG) accompany depression and its amelioration with ADs. In this study, the ...
The sweet drive test : refining phenotypic characterization of anhedonic behavi...
Pinheiro, António Mateus; Patrício, P.; Alves, N. D.; Santos, Ana R. Machado; Morais, Mónica; Bessa, J. M.; Sousa, Nuno; Pinto, LuisaMeasuring anhedonic behavior in rodents is a challenging task as current methods display only moderate sensitivity to detect anhedonic phenotype and, consequently, results from different labs are frequently incongruent. Herein we present a newly-developed test, the Sweet Drive Test (SDT), which integrates food preference measurement in a non-aversive environment, with ultrasonic vocalizations (USVs) recording. ...
The effects of chronic stress on hippocampal adult neurogenesis and dendritic p...
Bessa, J. M.; Pinto, Luisa; Morais, Mónica; Sousa, Nuno; Patrício, P.; Pinheiro, António Mateus; Almeida, Susana; Filipe, Augusto; Pedroso, PedroThere is accumulating evidence that adult neurogenesis and dendritic plasticity in the hippocampus are neuroplastic phenomena, highly sensitive to the effects of chronic stress and treatment with most classes of antidepressant drugs, being involved in the onset and recovery from depression. However, the effects of antidepressants that act through the selective inhibition of monoamine oxidase subtype A (MAO-A) i...
Sustained remission from depressive-like behavior depends on hippocampal neurog...
Pinheiro, António Mateus; Pinto, Luísa; Bessa, J. M.; Morais, Mónica; Alves, N. D.; Monteiro, S.; Patrício, P.; Almeida, O. F. X.; Sousa, NunoImpairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms...
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis a...
Patrício, P.; Pinheiro, António Mateus; Sousa, Nuno; Pinto, LuísaSince adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been associated with imbalances in adult hippocampal neurogenesis. These imbalances may ultimately reflect alterations at the cell cycle level, as a common mechanis...
Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset ...
Pinheiro, António Mateus; Patrício, P.; Bessa, J. M.; Sousa, Nuno; Pinto, LuísaBrain neuroplasticity is increasingly considered to be an important component of both the pathology and treatment of depressive spectrum disorders. Recent studies shed light on the relevance of hippocampal cell genesis and cortico-limbic dendritic plasticity for the development and remission from depressive-like behavior. However, the neurobiological significance of neuroplastic phenomena in this context is sti...