13 documents found, page 1 of 2
Silk sericin/chitosan supramolecular multilayered thin films as sustainable cyt...
Rosas, Miguel; Sousa, Cristiana F. V.; Pereira, Ana; Amaral, Adérito J. R.; Pesqueira, Tamagno; Patrício, Sónia G.; Fateixa, SaraSilk sericin (SS) has been widely discarded as a waste by the silk textile industry during the degumming process to obtain fibroin. However, in the past decade, an in-depth understanding of its properties and functions turned it into a high added-value biomaterial for biomedical applications. Herein, we report the molecular design and development of sustainable supramolecular multilayered nanobiomaterials encom...
A self‐sustaining hydrogels with autonomous supply of nutrients and bioactive d...
Zargarzadeh, Mehrzad; Gomes, Maria C.; Patrício, Sónia G.; Custódio, Catarina A.; Mano, João F.Photo-crosslinkable platelet lysate (PL)-based hydrogels have been proven to support human-derived cell cultures owing to their high content of bioactive molecules, such as cytokines and growth factors. As a unique self-maintained and biocompatible 3D scaffold, the recently reported self-feeding hydrogels with enzyme-empowered degradation capacity have shown high biological performance in vitro and in vivo. To ...
Freestanding magnetic microtissues for tissue engineering applications
Santos, Lúcia F.; Patrício, Sónia G.; Silva, Ana Sofia; Mano, João F.A long-sought goal in tissue engineering (TE) is the development of tissues able to recapitulate the complex architecture of the native counterpart. Microtissues, by resembling the functional units of living structures, can be used to recreate tissues' architecture. Howbeit, microfabrication methodologies fail to reproduce cell-based tissues with uniform shape. At the macroscale, complex tissues are already pro...
Bioengineered hierarchical bonelike compartmentalized microconstructs using nan...
Bjørge, Isabel M.; Sousa, Bárbara M. de; Patrício, Sónia G.; Silva, Ana Sofia; Nogueira, Liebert P.; Santos, Lúcia F.; Vieira, Sandra I.Fabrication of vascularized large-scale constructs for regenerative medicine remains elusive since most strategies rely solely on cell self-organization or overly control cell positioning, failing to address nutrient diffusion limitations. We propose a modular and hierarchical tissue-engineering strategy to produce bonelike tissues carrying signals to promote prevascularization. In these 3D systems, disc-shaped...
Liquefied microcapsules compartmentalizing macrophages and umbilical cord-deriv...
Nadine, Sara; Fernandes, Inês; Patrício, Sónia G.; Correia, Clara R.; Mano, João F.Extraordinary capabilities underlie the potential use of immune cells, particularly macrophages, in bone tissue engineering. Indeed, the depletion of macrophages during bone repair often culminates in disease scenarios. Inspired by the native dynamics between immune and skeletal systems, this work proposes a straightforward in vitro method to bioengineer biomimetic bone niches using biological waste. For that, ...
Green approaches for extraction, chemical modification and processing of marine...
Sacramento, Margarida M. A.; Borges, João; Correia, Fernando J. S.; Calado, Ricardo; Rodrigues, João M. M.; Patrício, Sónia G.; Mano, João F.Over the past few decades, natural-origin polysaccharides have received increasing attention across different fields of application, including biomedicine and biotechnology, because of their specific physicochemical and biological properties that have afforded the fabrication of a plethora of multifunctional devices for healthcare applications. More recently, marine raw materials from fisheries and aquaculture ...
Bioinstructive Layer-by-Layer-Coated Customizable 3D Printed Perfusable Microch...
Sousa, Cristiana F. V.; Saraiva, Catarina A.; Correia, Tiago R.; Pesqueira, Tamagno; Patrício, Sónia G.; Rial-Hermida, Maria Isabel; Borges, JoãoThe development of complex and large 3D vascularized tissue constructs remains the major goal of tissue engineering and regenerative medicine (TERM). To date, several strategies have been proposed to build functional and perfusable vascular networks in 3D tissue-engineered constructs to ensure the long-term cell survival and the functionality of the assembled tissues after implantation. However, none of them ha...
Thin silica-based microsheets with controlled geometry
Maciel, Marta; Patrício, Sónia G.; Borges, João; Levkin, Pavel A.; Correia, Tiago R.; Mano, J. F.A high demand for materials with defined geometry and size is required in a wide range of fields. Inorganic compounds, especially silica-based, arise as a cheap source and chemically flexible for the purpose. Silica display unique properties, like easy functionalization and good optical features making an interesting material to manipulate. In this work, we developed a method to create thin silica microsheets w...
Thermoelectric oxides: challenges and selected approaches for materials design
Kovalevsky, Andrei V.; Xie, Wenjie; Aguirre, Myriam H.; Ferreira, Nuno M.; Patrício, Sónia G.; Lopes, Diogo; Constantinescu, Gabriel; Costa, Florinda M.Sem resumo disponível.
Geometrically controlled liquefied capsules for modular tissue engineering stra...
Nadine, Sara; Patrício, Sónia G.; Barrias, Cristina C.; Choi, Insung S.; Matsusaki, Michiya; Correia, Clara R.; Mano, João F.A plethora of bioinspired cell-laden hydrogels are being explored as building blocks that once assembled are able to create complex and highly hierarchical structures recapitulating the heterogeneity of living tissues. Yet, the resulting 3D bioengineered systems still present key limitations, mainly related with limited diffusion of essential molecules for cell survival, which dictates the failure of most strat...