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The systemic immune response to collagen-induced arthritis and the impact of bo...
Teixeira, JH; Silva, AM; Almeida, MI; Bessa-Gonçalves, M; Cunha, C; Barbosa, MA; Santos, SGRheumatoid arthritis (RA) is a systemic disease that affects the osteoarticular system, associated with bone fragility and increased risk of fractures. Herein, we aimed to characterize the systemic impact of the rat collagen-induced arthritis (CIA) model and explore its combination with femoral bone defect (FD). The impact of CIA on endogenous mesenchymal stem/stromal cells (MSC) was also investigated. CIA indu...
Macrophages down-regulate gene expression of intervertebral disc degenerative m...
Silva, AJ; Ferreira, JR; Cunha, C; Corte-Real, JV; Bessa-Gonçalves, M; Barbosa, MA; Santos, SG; Gonçalves, RMLow back pain is a highly prevalent clinical problem and intervertebral disc (IVD) degeneration is now accepted as the major pathophysiological mechanism responsible for this condition. Accumulating evidence suggests that inflammation plays a crucial role in the progression of human IVD degeneration, with macrophages being pointed as the key immune cell players in this process since their infiltration in degene...