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Synthesis and in vitro evaluation of leishmanicidal activity of 7-hydroxy-4-phe...
Santos, Marcelo H. dos; Rosa, Isael A.; Almeida, Letícia de; Alves, Karina F.; Marques, Marcos J.; Fregnan, Antônio M.; Silva, Claudinei A.Eight coumarin derivatives (2–8) were synthesized from 7-hydroxy-4-phenylcoumarin 1 and were evaluated for their in vitro leishmanicidal activity against promastigote and amastigote forms of Leishmania amazonensis, as well their toxicity in murine macrophages. Compounds 4 and 7 showed the most significant results against promastigote forms of L. amazonensis. They were at least three-fold more active than 1 and ...
Date: 2018
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Origin: Oasisbr