3 documents found, page 1 of 1
Anti-malarial activity and toxicity of Aspidosperma nitidum Benth: a plant used...
Brandão, Dayse Lucia do Nascimento; Martins, Michel Tavares; Silva, Adreanne Oliveira; Almeida, Amanda Dias; Paula, Renata Cristina deThe objective of this work was to evaluate the antiplasmodial activity and toxicity of the extract and fractions obtained from the bark of Aspidosperma nitidum. The ethanol extract obtained from the powdered bark of plants was acid-base partitioned and phytochemically analyzed. The antiplasmodial activity, in vivo antimalarial activity and in vitro cytotoxicity were acessed. The selectivity index (SI) was calcu...
Triterpenes from minquartia guianensis (olacaceae) and in vitro antimalarial ac...
Cursino, Lorena Mayara de Carvalho; Nunez, C. V.; Paula, Renata Cristina de; Nascimento, Maria Fernanda Alves do; dos Santos, Pierre Alexandre LexandreMinquartia guianensis, popularly known as acariquara, was phytochemically investigated. The following triterpenes were isolated from the dichloromethane extract of leaves: lupen-3-one (1), taraxer-3-one (2) and oleanolic acid (3). The dichloromethane extract of branches yielded the triterpene 3β-methoxy-lup-20(29)-ene (4). The chemical structures were characterized by NMR data. Plant extracts, substance 3, squa...
Synthesis by click reactions and antiplasmodial activity of Lupeol 1,2,3-Triazo...
Borgati, Tatiane Freitas; Pereira, Guilherme Rocha; Brandão, Geraldo Célio; Santos, Juliana de Oliveira; Fernandes, Dayane Aparecida MoraisLupeol, a triterpene frequently found in Asteraceae plant species, showed moderate to low activity in different strains of Plasmodium falciparum, the most virulent malaria etiological agents. In this work, lupeol was isolated from Parahancornia fasciculata, a plant that is used to treat malaria in the Amazonia region. In the search of more activity lupeol derivatives, five new 1,2,3-triazole hybrid molecules we...