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The impact of combining SRSD instruction with a brief growth mindset interventi...

Ana Camacho; Rui Alves; Mariana Silva; Paula Ferreira; Nadine Correia; João R. Daniel

Self-Regulated Strategy Development (SRSD) is an evidence-based instructional approach combining background knowledge, writing, and self-regulation strategies to improve students' writing motivation and performance. While the positive impact of SRSD on writing performance variables is well-established, mixed findings were found for motivational variables, namely self-efficacy. In addition, the impact of SRSD on...



Placing hubs in CO2 pipelines: An application to industrial CO2 emissions in th...

Isabella Costa; Pedro Rochedo; Daniele Costa; Paula Ferreira; Madalena Araújo; Roberto Schaeffer; Alexandre Szklo

Carbon capture and geological storage (CCS) is a key technology for the World deep decarbonization. However, several challenges remain, such as the optimization of the carbon transportation infrastructures. This study proposes a methodology that applies the Kernel Density function in a geographic information system software and uses as input, CO2 emission sources data to identify emission clusters and emission ...


A mouse model reproducing the pathophysiology of neonatal group B streptococcal...

Paula Ferreira; Elva Bonifacio Andrade

Group B streptococcal (GBS) meningitis remains a devastating disease. The absence of an animal model reproducing the natural infectious process has limited our understanding of the disease and, consequently, delayed the development of effective treatments. We describe here a mouse model in which bacteria are transmitted to the offspring from vaginally colonised pregnant females, the natural route of infection. ...


Oral Therapeutic Vaccination with Streptococcus sobrinus Recombinant Enolase Co...

Marcia Dinis; Delfina Tavares; Isabel Veiga Malta; Antonio J M M Fonseca; Elva Bonifacio Andrade; Gabriela Trigo; Adilia Ribeiro; Amaldo Videira

Dental caries is among the more prevalent chronic human infections for which an effective human vaccine has not yet been achieved. Enolase from Streptococcus sobrinus has been identified as an immunomodulatory protein. In the present study, we used S. sobrinus recombinant enolase (rEnolase) as a target antigen and assessed its therapeutic effect in a rat model of dental caries. Wistar rats that were fed a cario...


Leukocyte populations and cytokine expression in the mammary gland in a mouse m...

Gabriela Trigo; Márcia Dinis; Ângela França; Elva Bonifácio Andrade; Rui M. Gil da Costa; Paula Ferreira; Delfina Tavares

Streptococcus agalactiae is a contagious, mastitis-causing pathogen that is highly adapted to survive in the bovine mammary gland. This study used a BALB/c mouse model of Streptococcus agalactiae mastitis to evaluate leukocyte populations in regional lymph nodes and cytokine expression in the mammary gland involved in the immune response against Streptococcus agalactiae. It was found that the bacteria replicate...


Interaction with human plasminogen system turns on proteolytic activity in Stre...

Vanessa Magalhaes; Isabel Veiga Malta; Maria Rosario Almeida; Marina Baptista; Adilia Ribeiro; Patrick Trieu Cuot; Paula Ferreira

Interactions of several microbial pathogens with the plasminogen system increase their invasive potential. In this study, we show that Streptococcus agalactiae binds human plasminogen which can be subsequently activated to plasmin, thus generating a proteolytic bacterium. S. agalactiae binds plasminogen via the direct pathway, using plasminogen receptors, and via the indirect pathway through fibrinogen receptor...




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