3 documents found, page 1 of 1
Chalcones and their B-aryl analogues as myeloperoxidase inhibitors: In silico, ...
Santos, Mariana Bastos dos [UNESP]; Carvalho Marques, Beatriz [UNESP]; Miranda Ayusso, Gabriela [UNESP]; Rocha Garcia, Mayara Aparecida [UNESP]Made available in DSpace on 2021-06-25T10:55:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); In the present study, a series of chalcones and their B-aryl analogues were prepared and evaluate as inhibitors of myeloperoxidase (MPO) chlorinating activity, using in vitro and ex vivo assays. Among these, B-thiophenyl chalcone (anal...
Identification of a Prenyl Chalcone as a Competitive Lipoxygenase Inhibitor: Sc...
Zeraik, Maria Luiza [UNESP]; Pauli, Ivani; Dutra, Luiz A. [UNESP]; Cruz, Raquel S. [UNESP]; Valli, Marilia [UNESP]; Paracatu, Luana C. [UNESP]Made available in DSpace on 2021-06-25T10:59:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-12; Fundação Araucária; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Cyclooxygenase (COX) and lipoxygenase (LOX) are key targets for the development of new anti-inflammatory agents. LOX, which is involved in the biosynth...
Experimental, DFT and docking simulations of the binding of diapocynin to human...
Venturini, Diego [UNESP]; Pastrello, Bruna [UNESP]; Zeraik, Maria Luiza [UNESP]; Pauli, Ivani; Andricopulo, Adriano DefiniMade available in DSpace on 2018-12-11T16:57:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-01-01; Diapocynin has been regarded as the active principle of apocynin, which is the most used inhibitor of NADPH oxidase. Here we performed a comprehensive study of the interaction of diapocynin with human serum albumin (HSA). We found that diapocynin binds with higher efficacy to site I of HSA and its bindi...