11 documents found, page 1 of 2
Retraction note: TRIB2 confers resistance to anti-cancer therapy by activating ...
Hill, Richard; Madureira, Patricia; Ferreira, Bibiana; Baptista, Ines; Machado, Susana; Colaҫo, Laura; dos Santos, Marta; Liu, Ningshu; Dopazo, AnaThe authors have retracted this article as it has come to their attention that several images were inappropriately processed and duplicated in multiple figures. In particular, the data were duplicated, and in some cases inverted, across several panels in Figures 2c, 2b, 3d and Supplementary Figure 5. Erroneous data were also included in Figure 2e, Supplementary Figure 1 and Supplementary Figure 8. We apologize ...
Androgens and low density lipoprotein-cholesterol interplay in modulating prost...
Cardoso, Henrique J.; Figueira, Marília I.; Carvalho, Tiago M.A.; Serra, Catarina D.M.; Vaz, Cátia V.; Madureira, Patricia; Socorro, SílviaBackground: Androgens, the known drivers of prostate cancer (PCa), have been indicated as important metabolic regulators with a relevant role in stimulating lipid metabolism. Also, the relationship between obesity and the aggressiveness of PCa has been established. However, it is unknown if the androgenic hormonal environment may alter the response of PCa cells to lipid availability. Purpose: The present study ...
Glutaminolysis is a metabolic route essential for survival and growth of prosta...
Cardoso, Henrique J.; Figueira, Marilia, I; Vaz, Catia V.; Carvalho, Tiago M. A.; Bras, Luis A.; Madureira, Patricia; Oliveira, Paulo J.Purpose Resistance to androgen-deprivation therapies and progression to so-called castrate-resistant prostate cancer (CRPC) remain challenges in prostate cancer (PCa) management and treatment. Among other alterations, CRPC has been associated with metabolic reprogramming driven by androgens. Here, we investigated the role of androgens in regulating glutaminolysis in PCa cells and determined the relevance of thi...
The role of Hypoxia in Glioblastoma radiotherapy resistance
Chédeville, Agathe L.; Madureira, PatriciaGlioblastoma (GB) (grade IV astrocytoma) is the most malignant type of primary brain tumor with a 16 months median survival time following diagnosis. Despite increasing attention regarding the development of targeted therapies for GB that resulted in around 450 clinical trials currently undergoing, radiotherapy still remains the most clinically effective treatment for these patients. Nevertheless, radiotherapy ...
Investigating glioblastoma response to hypoxia
Chédeville, Agathe L.; Lourdusamy, Anbarasu; Monteiro, Ana Rita; Hill, Richard; Madureira, PatriciaGlioblastoma (GB) is the most common and deadly type of primary malignant brain tumor with an average patient survival of only 15–17 months. GBs typically have hypoxic regions associated with aggressiveness and chemoresistance. Using patient derived GB cells, we characterized how GB responds to hypoxia. We noted a hypoxia-dependent glycolytic switch characterized by the up-regulation of HK2, PFKFB3, PFKFB4, LDH...
DIVERSet JAG compounds inhibit topoisomerase II and are effective against adult...
Howarth, Alison; Simms, Claire; Kerai, Nitesh; Allen, Olivia; Mihajluk, Karina; Madureira, Patricia; Sokratous, Giannis; Cragg, Simon; Lee, Sang Y.High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients. Clinical response is compounded by resistance to standard frontline antineoplastic agents, an absence of novel therapeutics, and poor in vitro models to evaluate these. We screened a range of recently identified anticancer compounds in conventional adult, ped...
Annexin A2 regulates AKT upon H2O2-dependent signaling activation in cancer cells
Castaldo, Stéphanie Anais; Ajime, Tom; Serrão Fernandes, Lina Gisela; Anastácio, Fábio; Rosa, Joana Teixeira; Giacomantonio, Carman AnthonyHydrogen peroxide (H2O2) is a main second messenger in oncogenic signaling networks including the Ras and the growth factor receptor pathways. This is achieved predominantly through the oxidation of redox-sensitive cysteine (Cys) residues in proteins resulting in changes to their structure and function. We previously identified annexin A2 (ANXA2) as a redox regulatory protein that plays an important cellular ro...
Mechanism of plasmin generation by S100A10
Miller, Victoria A.; Madureira, Patricia; Kamaludin, Ain Adilliah; Komar, Jeffrey; Sharma, Vandna; Sahni, Girish; Thewell, Craig; Longstaff, ColinPlasminogen (Pg) is cleaved to form plasmin by the action of specific plasminogen activators such as the tissue plasminogen activator (tPA). Although the interaction of tPA and Pg with the surface of the fibrin clot has been well characterised, their interaction with cell surface Pg receptors is poorly understood. S100A10 is a cell surface Pg receptor that plays a key role in cellular plasmin generation. In the...
TRIB2 confers resistance to anti-cancer therapy by activating the serine/threon...
Hill, Richard; Madureira, Patricia; Ferreira, Bibiana; Baptista, Inês; Machado, S.; Colaco, Laura; dos Santos, Marta; Liu, Ningshu; Dopazo, AnaIntrinsic and acquired resistance to chemotherapy is the fundamental reason for treatment failure for many cancer patients. The identification of molecular mechanisms involved in drug resistance or sensitization is imperative. Here we report that tribbles homologue 2 (TRIB2) ablates forkhead box O activation and disrupts the p53/MDM2 regulatory axis, conferring resistance to various chemotherapeutics. TRIB2 sup...
Annexin A2: The Importance of Being Redox Sensitive
Madureira, Patricia; Waisman, David M.Hydrogen peroxide (H2O2) is an important second messenger in cellular signal transduction. H2O2-dependent signalling regulates many cellular processes, such as proliferation, differentiation, migration and apoptosis. Nevertheless, H2O2 is an oxidant and a major contributor to DNA damage, protein oxidation and lipid peroxidation, which can ultimately result in cell death and/or tumourigenesis. For this reason, c...