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Rescue of susceptibility to second-line drugs in resistant clinical isolates of...
Maringolo-Ribeiro, Camila [UNESP]; Grecco, Julia A. [UNESP]; Bellato, Debora L. [UNESP]; Almeida, Aryadne L.; Baldin, Vanessa P.Made available in DSpace on 2022-04-28T18:45:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-23; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Sao Paulo State University; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Aim: Antibiotic resistance is one of the biggest threats to global health, and this study aimed better understand how the efflux pumps are relat...
Design, synthesis and antibacterial activity of chalcones against MSSA and MRSA...
Garcia, Mayara A.R. [UNESP]; Theodoro, Reinaldo S. [UNESP]; Sardi, Janaina C.O.; Santos, Mariana B. [UNESP]; Ayusso, Gabriela M. [UNESP]Made available in DSpace on 2022-04-29T08:32:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; Staphylococcus aureus is the one of the most successful modern pathogens. The same bacterium that lives as a skin and mucosal commensal can be transmitted in health-care and community-settings and causes severe infections. Thus, there is a great challenge for a discovery of novel anti-Staphylococcus aur...
A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through A...
De Grandis, Rone A. [UNESP]; Oliveira, Katia M.; Guedes, Adriana P. M.; dos Santos, Patrick W. S.; Aissa, Alexandre F.; Batista, Alzir A.Made available in DSpace on 2022-05-01T06:02:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-24; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Lapachol is a well-studied natural product that has been receiving great interest due to its anticancer properties that target oxidative stress. In the present work, two novel lapachol-containing ruthenium(II) complexes [Ru(Lap)(dppm)(bipy)]...
New silver(I) phosphino complexes: Evaluation of their potential as prospective...
Maldonado, Yndira Dolores; Scalese, Gonzalo; Manieri, Karyn Fernanda [UNESP]; Pavan, Fernando R. [UNESP]; Aguirre Méndez, Larry D.; Gambino, DinorahMade available in DSpace on 2022-05-01T11:07:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01; Despite being a preventable and curable disease, Tuberculosis (TB) is the world's top infectious killer. Development of new drugs is urgently needed. In this work, the synthesis and characterization of new silver(I) complexes, that include N′-[(E)-(pyridine-2-ylmethylene)pyrazine-2-carbohydrazide, HPCPH...
Profiling the Cymbopogon nardus Ethanol Extract and Its Antifungal Potential ag...
de Toledo, Luciani G. [UNESP]; Ramos, Matheus A.S. [UNESP]; Spósito, Larissa [UNESP]; Castilho, Elza M. [UNESP]; Pavan, Fernando R. [UNESP]Made available in DSpace on 2021-06-25T10:35:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01. Added 1 bitstream(s) on 2021-07-15T15:04:43Z : No. of bitstreams: 1 S0103-50532020000901926.pdf: 2171924 bytes, checksum: bda45f03c09642f18b9474d829b3b9c0 (MD5); The essential oil of Cymbopogon nardus, citronella, has been extensively studied. However, the chemical and biological properties of the ethan...
Antibacterial activity of a new monocarbonyl analog of curcumin MAC 4 is associ...
Polaquini, Carlos R. [UNESP]; Marques, Beatriz C. [UNESP]; Ayusso, Gabriela M. [UNESP]; Morão, Luana G. [UNESP]; Sardi, Janaína C.O.Made available in DSpace on 2021-06-25T10:52:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic application. Monocarbonyl analogs of curcumin (MACs) have bee...
Antimicrobial and antitumor activity of S-methyl dithiocarbazate Schiff base zi...
Ramilo-Gomes, Filipa; Addis, Yemataw; Tekamo, Israel; Cavaco, Isabel; Campos, Débora L. [UNESP]; Pavan, Fernando R. [UNESP]; Gomes, Clara S.B.Made available in DSpace on 2021-06-25T11:09:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01; Schiff bases (SB) obtained from S-methyl dithiocarbazate and aromatic aldehydes: salicylaldehyde (H2L1), o-vanillin (H2L2), pyridoxal (H2L3) and 2,6-diformyl-4-methylphenol (H3L4), and their corresponding Zn(II)-complexes (1–4), are synthesized. All compounds are characterized by elemental analyses, inf...
Differential miRNA expression in human macrophage-like cells infected with hist...
Pitangui, Nayla de Souza [UNESP]; Singulani, Junya de Lacorte [UNESP]; Sardi, Janaina de Cássia Orlandi; de Souza, Paula Carolina [UNESP]Made available in DSpace on 2021-06-25T11:10:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Universidade Estadual Paulista; Universidad Nacional Autónoma de México; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Histoplasma capsulatum affects healthy and immunocompromised individuals, sometimes causing a severe disease. This fungus has two morphotypes, the mycelial (infe...
Benzofuroxan Derivatives as Potent Agents against Multidrug-Resistant Mycobacte...
Fernandes, Guilherme F. S. [UNESP]; Campos, Débora L. [UNESP]; Da Silva, Isabel C. [UNESP]; Prates, João L. B. [UNESP]; Pavan, Aline R. [UNESP]Made available in DSpace on 2021-06-25T11:11:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-20; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Tuberculosis (TB) is currently the leading cause of death related to infectious diseases worldwide, as reported by the World Health Organization. Moreover, the increasing ...
Promising Ag(I) complexes with N-acylhydrazones from aromatic aldehydes and iso...
dos Santos, Paulo Victor P.; Ribeiro, Camila M. [UNESP]; Pavan, Fernando R. [UNESP]; Corbi, Pedro P.; Bergamini, Fernando R.G.; Carvalho, Marcos A.Made available in DSpace on 2021-06-25T11:12:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-15; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); In the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spec...