2 documents found, page 1 of 1
Molecular mechanisms and pharmacological interventions in the replication cycle...
Simabuco, Fernando; Tamura, Rodrigo; Pavan, Isadora Carolina Betim; Morale, Mirian; Ventura, ArmandoSARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), as well as SARS-CoV from 2003 and MERS-CoV from 2012, is a member of the Betacoronavirus genus of the Nidovirales order and is currently the cause of the pandemic called COVID-19 (or Coronavirus disease 2019). COVID-19 is characterized by cough, fever, fatigue, and severe cases of pneumonia and has affected more than 9.1 million people worldwide unti...
The effects of aging on rho-kinase and insulin signaling in skeletal muscle and...
Muñoz, Vitor Rosetto; Gaspar, Rafael Calais; Kuga, Gabriel Keine; Pavan, Isadora Carolina Betim; Simabuco, Fernando MoreiraMade available in DSpace on 2020-12-12T00:57:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-14; The insulin receptor substrate 1 regulates insulin-mediated glucose uptake and is a target of Rho-kinase (Rock); however, the relationship between age-related insulin resistance and Rock signaling specifically in skeletal muscle and adipose tissue is unknown. We evaluated the content and activity of Roc...