9 documents found, page 1 of 1
Profiling the Cymbopogon nardus Ethanol Extract and Its Antifungal Potential ag...
Toledo,Luciani G. de; Ramos,Matheus A. S.; Spósito,Larissa; Castilho,Elza M.; Pavan,Fernando R.; Lopes,Érica O.; Silva,Isabel C. da; Zocolo,Guilherme J.The essential oil of Cymbopogon nardus, citronella, has been extensively studied. However, the chemical and biological properties of the ethanolic extract (EE) of C. nardus have not been evaluated. The aim of this study was to characterize the chemical composition of the EE of C. nardus and its active fraction (FrD). Moreover, the cytotoxic and antifungal properties of these extracts against Candida species wit...
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol...
Manda,Bhaskar R.; Prasad,Avvari N.; Thatikonda,Narendar R.; Lacerda Jr.,Valdemar; Barbosa,Layla R.; Santos,Heloa; Romão,Wanderson; Pavan,Fernando R.The synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by 1H and 13C NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. ...
Structure/Activity of PtII/N,N-Disubstituted-N'-acylthiourea Complexes: Anti-Tu...
Plutín,Ana M.; Alvarez,Anislay; Mocelo,Raúl; Ramos,Raúl; Sánchez,Osmar C.; Castellano,Eduardo E.; Silva,Monize M. da; Villarreal,WilmerThe syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of PtII/PPh3/N,N-disubstituted-N'-acylthioureas complexes with general formulae [Pt(PPh3)2(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N'-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic reso...
Anti-Mycobacterium tuberculosis and Cytotoxicity Activities of Ruthenium(II)/ B...
Lima,Benedicto A. V.; Corrêa,Rodrigo S.; Graminha,Angelica E.; Kuznetsov,Aleksey; Ellena,Javier; Pavan,Fernando R.; Leite,Clarice Q. F.The [Ru(Spym)(bipy)(P–P)]PF6, [Spym = pyrimidine-2-thiolate anion; P–P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1'-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and...
Synthesis, Antitubercular and Leishmanicidal Evaluation of Resveratrol Analogues
Coimbra,Elaine S.; Santos,Juliana A.; Lima,Larissa L.; Machado,Patrícia A.; Campos,Débora L.; Pavan,Fernando R.; Silva,Adilson D.In this paper we continue our efforts in the search for new Schiff bases as resveratrol analogues as promising antitubercular and antileishmanial agents. Compounds were evaluated in vitro against Mycobacterium tuberculosis and Leishmania species. Compounds showed varying activity against promastigotes of all Leishmania species tested (concentration leading to reduction of 50% of parasite growth-IC50 values rang...
Cobalt(III) complexes with thiosemicarbazones as potential anti-Mycobacterium t...
Oliveira,Carolina G.; Maia,Pedro Ivo da S.; Miyata,Marcelo; Pavan,Fernando R.; Leite,Clarice Q. F.; Almeida,Eduardo Tonon de; Deflon,Victor M.CoIII complexes derived from 2-acetylpyridine N(4)-R thiosemicarbazone (Hatc-R, R = alkyl, aryl) have been characterized by elemental analysis, FTIR, UV-Visible and ¹H NMR spectroscopies, cyclic voltammetry (CV), conductimetry measurements and single crystal X-ray diffractometry. The results obtained are consistent with the oxidation of the CoII center to CoIII upon coordination of the monoanionic N,N,S-trident...
Paepalanthus spp: antimycobacterial activity of extracts, methoxylated flavonoi...
Moreira,Raquel R. D.; Martins,Gilmarcio Z.; Pietro,Rosemeire C. L. R.; Sato,Daisy N.; Pavan,Fernando R.; Leite,Sergio R.A.; Vilegas,WagnerPaepalanthus spp., Eriocaulaceae, are native plants from Brazil known as "sempre-vivas" (everlasting flowers). In this work, we evaluated the potential anti-mycobacterial activity of two methoxylated flavonoids (flavonoid 7-methylquercetagetin and 7-methylquercetagetin-4'-O-β-D-glucopyranoside) isolated and identified from P. latipes and the naphthopyranone fractions from P. bromeliodes ethanolic extracts. The ...
Palladium(II) complexes with thiosemicarbazones: syntheses, characterization an...
Maia,Pedro I. da S.; Graminha,Angélica; Pavan,Fernando R.; Leite,Clarice Q. F.; Batista,Alzir A.; Back,Davi F.; Lang,Ernesto S.; Ellena,JavierThree PdII complexes were prepared from N(4)-substituted thiosemicarbazones: [Pd(aptsc)(PPh3)](NO3)H2O, 1, [Pd(apmtsc)(PPh3)](NO3), 2, and [Pd(apptsc)(PPh3)](NO3)H2O, 3, where PPh3 = triphenylphosphine; Haptsc = 2-acetylpyridine-thiosemicarbazone; Hapmtsc = 2-acetylpyridine-N(4)-methyl-thiosemicarbazone and Happtsc = 2-acetylpyridine-N(4)-phenyl-thiosemicarbazone. All complexes were characterized by elemental...
In vitro anti-Mycobacterium tuberculosis activity of some Brazilian "Cerrado" p...
Pavan,Fernando R.; Sato,Daisy N.; Higuchi,Célio T.; Santos,Adolfo C. B.; Vilegas,Wagner; Leite,Clarice Q. EThe aim of this work was to carry out a screening of some plants of this Brazilian region with activity against Mycobacterium tuberculosis. Chloroform and methanol extracts of 37 plant species distributed among 17 families from Brazilian "Cerrado" which were tested against M. tuberculosis H37Rv and the Minimum Inhibitory Concentration (MIC) was determined by the use of Microplate Alamar Blue Assay (MABA). Crude...