2 documents found, page 1 of 1
Apoptosis in human liver carcinoma caused by gold nanoparticles in combination ...
Araújo Júnior, Raimundo Fernandes de; Pessoa, Jonas B.; Cruz, Luis J.; Chan, Alan B.; Miguel, Emilio de Castro; Cavalcante, Rômulo S.In cancers, apoptosis signaling pathways and cell survival and growth pathways responsible for resistance to conventional treatments, such as Pi3K/Akt/mTOR and mitogen-activated protein kinase (MAPK) become dysregulated. Recently, alternative treatments to promote tumor cell death have become important. The present study reports on the antitumor and cytoprotective action of gold nanoparticles (GNPs) and carvedi...
Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidat...
Carvalho, Thaís Gomes de; Garcia, Vinícius Barreto; Araújo, Aurigena Antunes de; Gasparotto, Luiz Henrique da Silva; Silva, HeloizaThis study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and Methamphetamine (METH). The liver injury was induced by gavage administrations of 30% alcoholic solution (7 g/kg) once a day during 28 days, followed by METH (10 mg/kg) on the 20th and 28th days of treatment. GNPs treatment (724.96 µg/kg) duri...