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Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synap...
Carvalho da Silva, António M; Lemos, Cristina; Silva, Henrique Bernardo; Ferreira, Ildete L.; Tomé, Ângelo R.; Rego, A. Cristina; Cunha, Rodrigo A.Alzheimer's disease (AD) is characterized by progressive memory deficits accompanied by synaptic and metabolic deficits, namely of mitochondrial function. AD patients also display a disrupted circadian pattern. Thus, we now compared memory performance, synaptic plasticity, and mitochondria function in 24-week-old non-transgenic (non-Tg) and triple transgenic male mice modeling AD (3xTg-AD) at Zeitgeber 04 (ZT-4...
Data: 2022
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Origem: Estudo Geral - Universidade de Coimbra