2 documents found, page 1 of 1
Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues agai...
Barbosa Da Silva, Elany; Sharma, Vandna; Hernandez-Alvarez, Lilian [UNESP]; Tang, Arthur H.; Stoye, Alexander; O’Donoghue, Anthony J.Made available in DSpace on 2022-04-29T08:40:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-10; Gallinamide A, a metabolite of the marine cyanobacterium Schizothrix sp., selectively inhibits cathepsin L-like cysteine proteases. We evaluated the potency of gallinamide A and 23 synthetic analogues against intracellular Trypanosoma cruzi amastigotes and the cysteine protease, cruzain. We determined t...
Long-term population dynamics: Theory and reality in a peatland ecosystem
Connor, Simon; Colombaroli, Daniele; Confortini, Federico; Gobet, Erika; Ilyashuk, Boris P.; Ilyashuk, Elena A.; van Leeuwen, Jacqueline F. N.1. Population dynamics is a field rich in theory and poor in long-term observational data. Finding sources of long-term data is critical as ecosystems around the globe continue to change in ways that current theories and models have failed to predict. Here we show how long-term ecological data can improve our understanding about palaeo-population change in response to external environmental factors, antecedent ...