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Citrinin against breast cancer: A cytogenotoxicological study
de Oliveira Filho, José Williams Gomes; Andrade, Teresinha de Jesus Aguiar dos Santos; de Lima, Rosália Maria Tôrres; dos Reis, Antonielly CampinhoMade available in DSpace on 2020-12-12T02:20:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; Breast cancer is one of the most lethal types of cancer and a leading cause of mortality among Women worldwide. Citrinin (CIT), a polyketide extracted from the fungus Penicillium citrinum, exhibits a wide range of biological activities such as antibacterial, antifungal, and cytotoxic effects. The aim of...
Toxicogenetic profile of rats treated with aqueous extract from Morinda citrifo...
Moraes, Germano Pinho de; Alencar, Marcus Vinícius Oliveira Barros de; Islam, Torequl; Araújo, Lidiane da Silva; Gomes, Débora Cássia VieiraMorinda citrifolia ( (Family: Rubiaceae) ) is extensive ly use d in traditional med icine due to its anti - inflammatory, antimicrobial, antitumoral , and anti - hypertensive act ivities . However, t here is no substantial data about hepatotoxic and toxicogenetic effects . This study evaluated bioch emical changes and hepatotoxic, genotoxic , and mu tagenic effects of aqueous extract of the fruit of M. citrifol...
Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity
Islam, Torequl; Streck, Leticia; Paz, Márcia Fernanda Correia Jardim; Sousa, João Marcelo de Castro e; Alencar, Marcus Vinícius Oliveira Barros deThe study prepared a nanoemulsion with a diterpenoid isoprenoid alcohol called phytol (PYT) and subsequently tested it for antioxidant capacity. For this, PYT-loaded nanoemulsion was prepared by phase inversion method and both PYT-containing nanoemulsion (PNE) and PYT-free nanoemulsion (PFNE) (2-16 µM) were tested for antiradical activity (DPPH•: 1,1-dipheny-picrylhydrazyl radical; ABTS•+: azino-bisethylbenzthi...
Cytogenotoxic and oxidative status evaluation of Morinda citrifolia
Moraes, Germano Pinho de; Alencar, Marcus Vinícius Oliveira Barros de; Islam, Torequl; Araújo, Lidiane da Silva; Sobral, André Luiz PinhoCancer is one of the most leading causes of death worldwide. Morinda citrifolia was reported to have antitumor effects. Cisplatin (CDDP), Doxorubicin (DOX) and Cyclophosphamid (CPA) are the known effective chemotherapeutics, despite of having several side effects. This study evaluated antitumoral and oxidative effects of the aqueous extract of the fruit of M. critrifolia (AEMC) (15, 30, 60 and 120 µg/mL) in com...
Genotoxicity and DNA repair indicative in blood cells after occupational exposu...
Silva, Ronald Gerard; Alencar, Marcus Vinícius Oliveira Barros de; Teixeira, Jadson Silva T; Silva, Reyca Rodrigues eOccupational exposure to ionizing radiation (IR) can damage DNA. The study evaluated the genotoxic profile and repair indicatives of DNA from peripheral blood lymphocytes of health workers exposed occupationally to IR by adopting comet assay. Biomonitoring was done with ninety individuals; among them 45 were health professionals and the rests were non-professionals. Blood samples were collected after 48 h (2 d;...