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Evaluation of diagnosis and treatment practices of Brazilian neurologists among...
Marin,Cássia Elisa; Callegaro,Dagoberto; Lana-Peixoto,Marco Aurélio; Fernández,Oscar; Gomes Neto,Antonio Pereira; Vasconcelos,Claudia Cristina FerreiraABSTRACT Background: Recent changes to the diagnostic criteria for multiple sclerosis (MS) and new medications have had a major impact on the way in which specialists manage the disease. Objective: To investigate factors considered by Brazilian neurologists in managing MS, and to identify how these contribute to diagnosis and treatment. Methods: Potential participants were selected by a steering committee (MS e...
Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy ...
Marques,Vanessa Daccach; Passos,Giordani Rodrigues dos; Mendes,Maria Fernanda; Callegaro,Dagoberto; Lana-Peixoto,Marco AurélioABSTRACT The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurolo...
Serological profile of John Cunningham virus (JCV) in patients with multiple sc...
Branco,Luciana Prats; Adoni,Tarso; Apostolos-Pereira,Samira Luisa; Brooks,Joseph Bruno Bidin; Correa,Eber Castro; Damasceno,Carlos AugustoABSTRACT Treatment options for multiple sclerosis (MS) have changed over the last few years, bringing about a new category of drugs with more efficient profiles. However, these drugs have come with a whole new profile of potential adverse events that neurologists have to learn well and quickly. One of the most feared complications of these MS treatments is progressive multifocal leukoencephalopathy caused by th...
High levels of alexithymia in patients with multiple sclerosis
Eboni,Audred Cristina Biondo; Cardoso,Mariana; Dias,Felipe Moreira; Gama,Paulo Diniz da; Gomes,Sidney; Goncalves,Marcus Vinicius MagnoAbstract Alexithymia is a personality trait characterized by difficulties identifying and describing feelings. Some researchers describe high levels of alexithymia among patients with multiple sclerosis (MS) but literature data on this subject are scarce. Objective: The objective of the present study was to characterize findings of alexithymia in patients with MS. Methods: This cross-sectional case-control stud...
Safety of switching from natalizumab straight into fingolimod in a group of JCV...
Fragoso,Yara Dadalti; Alves-Leon,Soniza Vieira; Becker,Jefferson; Brooks,Joseph Bruno Bidin; Correa,Eber Castro; Damasceno,Alfredo; Gama,Paulo Diniz daABSTRACT Objective To assess safety of the switch between natalizumab and fingolimod without a washout period. Methods Prospective data on 25 JCV positive patients who underwent this medication switch were collected and analyzed. Results After a median period of nine months from the medication switch, there were no safety issues to report. The patients had good disease control and no adverse events were reporte...
The real-life experience with cardiovascular complications in the first dose of...
Fragoso,Yara Dadalti; Arruda,Christian Cardoso; Arruda,Walter Oleschko; Brooks,Joseph Bruno Bidin; Damasceno,AlfredoFingolimod is a new and efficient treatment for multiple sclerosis (MS). The drug administration requires special attention to the first dose, since cardiovascular adverse events can be observed during the initial six hours of fingolimod ingestion. The present study consisted of a review of cardiovascular data on 180 patients with MS receiving the first dose of fingolimod. The rate of bradycardia in these patie...
Natalizumab adverse events are rare in patients with multiple sclerosis
Fragoso,Yára Dadalti; Alves-Leon,Soniza Vieira; Arruda,Walter Oleschko; Carvalho,Margarete de Jesus; Comini-Frota,Elizabeth Regina; Corrêa,Éber CastroObjective To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the study. The total number of infusions was 1,042. Seventy-nin...
Antiparasitic antibodies occur with similar frequency in patients with clinical...
Fonseca-Papavero,Fabiana Cruz Gomes da; Callegaro,Dagoberto; Gama,Paulo Diniz da; Livramento,Jose Antonio; Vaz,Adelaide Jose; Machado,Luis dos RamosThe "hygiene hypothesis" postulates an inverse relationship between the prevalence of parasitic infections and the frequency of multiple sclerosis (MS). Objective: It was to study whether antibodies against parasites could be demonstrated more frequently in blood serum from MS patients with oligoclonal bands (OCB) than from MS patients without OCB. Methods: We studied serum samples from 164 patients who had pre...
Nearly one-half of Brazilian patients with multiple sclerosis using natalizumab...
Fragoso,Yara Dadalti; Mendes,Maria Fernanda; Arruda,Walter Oleschko; Becker,Jefferson; Brooks,Joseph Bruno Bidin; Carvalho,Margarete de JesusObjective Natalizumab is a new and efficient treatment for multiple sclerosis (MS). The risk of developing progressive multifocal leukoencephalopathy (PML) during the use of this drug has created the need for better comprehension of JC virus (JCV) infection. The objective of the present study was to assess the prevalence of JCV-DNA in Brazilian patients using natalizumab. Method Qualitative detection of the JCV...
Multiple sclerosis starting before the age of 18 years: the Brazilian experience
Fragoso,Yara Dadalti; Ferreira,Maria Lucia Brito; Morales,Nivea de Macedo Oliveira; Arruda,Walter Oleschko; Brooks,Joseph Bruno BidinMultiple sclerosis (MS) starting in childhood and adolescence poses a challenge for diagnosis and management of the disease. The aim of the present study was to assess the characteristics of early onset MS in Brazilian patients. Methods Retrospective data collection from specialized MS units. Results From 20 MS units in 11 Brazilian states, 117 cases of MS starting before the age of 18 years were collected. The...