4 documents found, page 1 of 1
Development of a decellularized extracelular matrix from porcine aorta for hear...
Reis, Mariana S.; Rosadas, Marta; Ho, Chou I.; Sousa, Teresa; Pazmino, Carlos; Costa, João; Vervenne, Thibault; Oliveira, Ana L.; Ribeiro, Viviana P.Cardiovascular diseases are the leading cause of adult mortality worldwide, according to the World Health Organization [1]. An important surgical approach for treating diseased aortic valves is the Ross procedure, in whic the affected aortic valve is replaced with an autograft from the patient’s own pulmonary valve.
Supercritical CO2-assisted decellularization: advanced pancreatic tissue platfo...
Sá, Simone C.; Pazmino, Carlos; Sá, Joana; Amorim, Sara; Ribeiro, Viviana P.; Costa, Raquel; Oliveira, Ana L.Introduction: Decellularization is a procedure that aims to remove the cellular and antigenic material of a tissue while preserving its extracellular matrix (ECM) and biological properties. Decellularized ECM offers a natural microenvironment with significant potential for use in cell-based therapies and tissue regeneration [1]. Different protocols have been employed to decellularize tissues and organs. However...
Unlocking the potential of supercritical CO₂ for an efficient pancreatic tissue...
Sá, Simone C.; Pazmino, Carlos; Sá, Joana; Amorim, Sara; Ribeiro, Viviana P.; Costa, Raquel; Oliveira, Ana L.Decellularization, the process of removing cells from a tissue or organ while preserving the extracellular matrix (ECM), often employs harsh chemical solvents, compromising ECM integrity. This is particularly damaging in case of soft tissues. Supercritical carbon dioxide (scCO2), achieved at 31ºC and 74Bar, is an alternative solvent which presents high transfer rates and diffusivity while being chemically inert...
Unlocking the potential of supercritical CO₂ for an efficient pancreatic tissue...
Sá, Simone C.; Pazmino, Carlos; Sá, Joana; Amorim, Sara; Ribeiro, Viviana P.; Costa, Raquel; Oliveira, Ana L.Introduction: Tissue decellularization is a procedure that removes cellular and antigenic material from specific tissues, while preserving the extracellular matrix (ECM), with conditions tailored to the tissue's properties. The decellularized ECM is a promising material for cell-based therapies or for tissue defect repair through the development of scaffolds and membranes, among others. Pancreas is an organ tha...