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Exercise training impacts skeletal muscle remodelling induced by metabolic synd...
Nogueira-Ferreira, Rita; Santos, Inês; Ferreira, Rita; Fontoura, Dulce; Sousa-Mendes, Cláudia; Falcão-Pires, Inês; Lourenço, André P.Metabolic syndrome (MetS), characterized by a set of conditions that include obesity, hypertension, and dyslipidemia, is associated with increased cardiovascular risk. Exercise training (EX) has been reported to improve MetS management, although the underlying metabolic adaptations that drive its benefits remain poorly understood. This work aims to characterize the molecular changes induced by EX in skeletal mu...
Comparing one sample’s observed survival with the expected in the general popul...
Moreira, Raquel; Saraiva, Francisca A.; Cerqueira, Rui J.; Ferreira, Ana F.; Amorim, Mário J.; Barros, António S.; Pinho, Paulo; Lourenço, André P.
EARLY AND MIDTERM OUTCOMES FOLLOWING AORTIC VALVE REPLACEMENT WITH MECHANICAL V...
Rocha, Rafael; Cerqueira, Rui J.; Saraiva, Francisca; Moreira, Sara; Barros, António S.; Almeida, Jorge; Amorim, Mário J.; Lourenço, André P.Objectives: To compare 7-year survival and freedom from reoperation, as well as early clinical and hemodynamic outcomes, after surgical aortic valve replacement (SAVR) with mechanical or bioprosthetic valves in patients aged 50-70 years. Methods: single-center retrospective cohort study including adults aged 50-70 years who underwent SAVR in 2012 with a mechanical or bioprosthetic valve. Median follow-up was 7 ...
Reconstructing survival data from published Kaplan-Meier curves: an algorithm v...
Saraiva, Francisca Almeida; Leite-Moreira, João P.; Lourenço, André P.; Barros, António S.; Leite-Moreira, AdelinoBackground: The number of health-related publications has been exponential in the recent decade. Indeed, cardiovascular area includes more than 670k papers published at MEDLINE [((cardiovascular) NOT ((("Animals"[Mesh] NOT ("Animals"[Mesh] AND "Humans"[Mesh])))], of which, more than 20k are related to coronary artery bypass grafting (CABG). We are witnessing a 6% increase in publications per year. The growth in...
Excessive salt consumption in food: a greater risk than hypertension?
Lourenço, André P.; Macedo, Inês E.
Time course and mechanisms of left ventricular systolic and diastolic dysfuncti...
Correia-Pinto, Jorge; Henriques-Coelho, Tiago; Roncon-Albuquerque, Roberto; Lourenço, André P.; Rocha, Gustavo Filipe Melo AlvesAlthough pulmonary hypertension (PH) selectively overloads the right ventricle (RV), neuroendocrine activation and intrinsic myocardial dysfunction have been described in the left ventricle (LV). In order to establish the timing of LV dysfunction development in PH and to clarify underlying molecular changes, Wistar rats were studied 4 and 6 weeks after subcutaneous injection of monocrotaline (MCT) 60 mg/kg (MCT...