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Endophilin-A coordinates priming and fusion of neurosecretory vesicles via inte...

Gowrisankaran, Sindhuja; Houy, Sébastien; Del Castillo, Johanna G Peña; Steubler, Vicky; Gelker, Monika; Kroll, Jana; Pinheiro, Paulo S.

Endophilins-A are conserved endocytic adaptors with membrane curvature-sensing and -inducing properties. We show here that, independently of their role in endocytosis, endophilin-A1 and endophilin-A2 regulate exocytosis of neurosecretory vesicles. The number and distribution of neurosecretory vesicles were not changed in chromaffin cells lacking endophilin-A, yet fast capacitance and amperometry measurements re...

Date: 2020   |   Origin: Estudo Geral - Universidade de Coimbra
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