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Sustained macrophage reprogramming is required for CD8+ T cell–dependent long-t...
Jardim, Carolina; Bica, Marta; Reis-Sobreiro, Mariana; Mota, Afonso Teixeira da; Lopes, Raquel; Ferreira-Pinto, Miguel Alexandre; Sousa, Neuza S.Tumor-associated macrophages (TAM) exhibit a dual role in tumor progression and antitumor immunity. However, understanding the functional states and molecular mechanisms of antitumor TAMs remains a challenge. Herein, we show that intratumoral administration of a combination of agonists against TLR3 and CD40 [hereafter termed myeloid cell treatment (MCT)] reprogrammed TAMs in situ to adopt a protective antitumor...
Interplay between liver and blood stages of Plasmodium infection dictates malar...
Chora, Ângelo Ferreira; Marques, Sofia; Lisboa Gonçalves, Joana; Lima, Priscila; Gomes Da Costa, Daniel; Fernandez-Ruiz, Daniel; Marreiros, Maria InêsPlasmodium replicates within the liver prior to reaching the bloodstream and infecting red blood cells. Because clinical manifestations of malaria only arise during the blood stage of infection, a perception exists that liver infection does not impact disease pathology. By developing a murine model where the liver and blood stages of infection are uncoupled, we showed that the integration of signals from both s...
Immunopathology and Trypanosoma congolense parasite sequestration cause acute c...
De Niz, Mariana; Silva Pereira, Sara; Serre, Karine; Ouarné, Marie; Coelho, Joana E; Franco, Claudio; Figueiredo, Luisa M.Trypanosoma congolense causes a syndrome of variable severity in animals in Africa. Cerebral trypanosomiasis is a severe form, but the mechanism underlying this severity remains unknown. We developed a mouse model of acute cerebral trypanosomiasis and characterized the cellular, behavioral, and physiological consequences of this infection. We show large parasite sequestration in the brain vasculature for long p...
Trypanosoma brucei triggers a broad immune response in the adipose tissue
Machado, Henrique; Rebelo, Tiago; Sequeira, Mariana; Trindade, Sandra; Carvalho, Tânia; Rijo-Ferreira, Filipa; Rentroia-Pacheco, Barbara; Serre, KarineAdipose tissue is one of the major reservoirs of Trypanosoma brucei parasites, the causative agent of sleeping sickness, a fatal disease in humans. In mice, the gonadal adipose tissue (AT) typically harbors 2-5 million parasites, while most solid organs show 10 to 100-fold fewer parasites. In this study, we tested whether the AT environment responds immunologically to the presence of the parasite. Transcriptome...
Bringing macrophages to the frontline against cancer: current Immunotherapies t...
Reis-Sobreiro, Mariana; Teixeira da Mota, Afonso; Jardim, Carolina; Serre, KarineMacrophages are found in all tissues and display outstanding functional diversity. From embryo to birth and throughout adult life, they play critical roles in development, homeostasis, tissue repair, immunity, and, importantly, in the control of cancer growth. In this review, we will briefly detail the multi-functional, protumoral, and antitumoral roles of macrophages in the tumor microenvironment. Our objectiv...
Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in...
Castro, Flávia; Pinto, Marta L.; Pereira, Catarina L.; Serre, Karine; Barbosa, Mário A.; Vermaelen, Karim; Gärtner, Fátima; Gonçalves, Raquel M.Radiotherapy (RT) is an essential treatment modality for several types of cancer. Despite its therapeutic potential, RT is frequently insufficient to overcome the immunosuppressive nature of the tumor microenvironment, failing to control tumor metastases. Innovative immunomodulatory strategies, like immunostimulatory biomaterials could be used to boost the immunogenic effects of RT. Herein, we addressed the syn...
Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
Meireles, Patricia; Brás, Daniela; Fontinha, Diana; Chora, Ângelo Ferreira; Serre, Karine; Mendes, António M.; Prudêncio, MiguelPlasmodium parasites, causative agents of malaria, scavenge host nutrients to sustain their intracellular replication. Modulation of the host's nutritional status can potentially help control infection by limiting the parasite's access to nutrients, or by boosting the immune system. Here, we show that dietary supplementation of mice employing a combination of arginine (R) with two additional amino acids, lysine...
The Portuguese Society for Immunology - SPI: history and mission
Alves, Nuno L.; Carvalho, Agostinho; Serre, Karine; Martins, Vera C.; Saraiva, MargaridaThe SPI (Figure 1) was founded in 1973 by group of 13 immunologists who felt the need to create a platform dedicated to education, interaction and state of the art discussion in fundamental and clinical immunology in Portugal. Since then, the Portuguese scientific landscape has tremendously expanded in size, quality and international competitiveness, with the SPI and its members following the same trend. Curren...
MicroRNA-146a controls IFN-g production and functional plasticity of murine gd ...
Schmolka, Nina; Papotto, Pedro H.; Romero, Paula Vargas; Amado, Tiago; Enguita, Francisco J.; Amorim, Ana; Gordon, Katrina E.; Boldin, Markγδ T cells have emerged as key providers of the proinflammatory cytokines interleukin 17 (IL-17) and interferon-γ (IFN-γ) in various models of infection, inflammation, and autoimmunity. Our previous epigenetic and transcriptional analyses have shown that whereas CD27+ γδ T cells are committed to IFN-γ expression, the IL-17 producing CD27- subset has limited plasticity to co-express both cytokines under inflamma...
MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1
Schmolka, Nina; Papotto, Pedro H.; Romero, Paula Vargas; Amado, Tiago; Enguita, Francisco J.; Amorim, Ana; Rodrigues, Ana F.; Gordon, Katrina E.γδ T cells are major providers of proinflammatory cytokines. They are preprogrammed in the mouse thymus into distinct subsets producing either interleukin-17 (IL-17) or interferon-γ (IFN-γ), which segregate with CD27 expression. In the periphery, CD27- γδ (γδ27-) T cells can be induced under inflammatory conditions to coexpress IL-17 and IFN-γ; the molecular basis of this functional plasticity remains to be det...