13 documents found, page 1 of 2
World Heart Federation Cholesterol Roadmap: The Portuguese case
Abreu, A; Dores, H; Gonçalves, L; Franco, F; Silveira, C; Proença, G; Teresa Timóteo, A; Cardim, N; Pedro, M; Fiuza, M; Ferreira, D; Bento, LAtherosclerotic cardiovascular disease (ASCVD) remains the major cause of premature death and disability; effective cardiovascular (CV) risk prevention is fundamental. The World Heart Federation (WHF) Cholesterol Roadmap provides a framework for national policy development and aims to achieve ASCVD prevention. At the invitation of the WHF, a group of experts from the Portuguese Society of Cardiology (SPC), addr...
Using educational networks to promote internationalization experiences in physi...
Alves Lopes, António; Prado, A; Pereira, A; Leão, C; Martins, Maria Elisabete; Valente, F; Mazzoli-Rocha, F; Pacheco, G; Sousa, J. Luís; Pedro, MIntroduction and Objectives: The Academic Network of Health Sciences of Lusofonia (RACS - racslusofonia.org) was created in 2016, with the mission of promoting training and scientific cooperation in health sciences, between higher education institutions and research centers in different countries and Portuguese speaking communities. Within the Physiotherapy Education Group of RACS we develop a project with a se...
Using educational networks to promote internationalization experiences in physi...
Alves Lopes, António; Prado, A; Pereira, A; Leão, C; Martins, Maria Elisabete; Valente, F; Mazzoli-Rocha, F; Pacheco, G; Sousa, J. Luís; Pedro, MIntroduction and Objectives: The Academic Network of Health Sciences of Lusofonia (RACS - racslusofonia.org) was created in 2016, with the mission of promoting training and scientific cooperation in health sciences, between higher education institutions and research centers in different countries and Portuguese speaking communities. Within the Physiotherapy Education Group of RACS we develop a project with a se...
Development and characterization of PLGA nanoparticles containing 1,3-dihydroxy...
Teixeira, M; Pedro, M; Nascimento, MSJ; Pinto, MMM; Barbosa, C.M.Interest on xanthones has been growing considerably due to their broad spectrum of biological activities. 1,3-Dihydroxy-2-methylxanthone (DHMXAN) showed a significant inhibitory effect on the growth of MCF-7 cancer cells. DHMXAN-loaded nanosphere and nanocapsule formulations were prepared by the solvent displacement technique with the aim of improving the delivery of this poorly water-soluble compound. Moreover...
Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyran...
Valente, C; Pedro, M; Ascenso, JR; Abreu, PM; Nascimento, MSJ; Ferreira, MJUThe structures of euphopubescenol and euphopubescene, two new macrocyclic jatrophane diterpene polyesters, isolated from the whole dried plant of Euphorbia pubescens, were established as 5alpha,8alpha,15beta-triacetoxy-3alpha-benzoyloxy-4alpha-hydroxy-9,14-dioxo-13betaH-jatropha-6(17),11E-diene (1) and 3beta,7beta,8beta,9alpha,14alpha,15beta-hexa-acetoxy-2betaH-jatropha-5E,11E-diene (2) by 1D- and 2D-NMR (COSY,...
Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other const...
Valente, C; Pedro, M; Duarte, A; Nascimento, MSJ; Abreu, PM; Ferreira, MJUA new jatrophane diterpene, pubescenol (1), known ent-abietane lactones, helioscopinolide A (2) and B (3), and taraxerone, 24-methylenecycloartanol, and vanillin have been isolated from Euphorbia pubescens. Diterpenes 1-3 and previously described pubescene D (4) were shown to be moderate inhibitors of the growth of MCF-7, NCI-H460, and SF-268 human tumor cell lines, whereas compounds 2 and 3 also exhibited sign...
Catechols from abietic acid
Gigante, B; Santos, C; Silva, AM; Curto, MJM; Nascimento, MSJ; Pinto, E; Pedro, M; Cerqueira, F; Pinto, MM; Duarte, MP; Laires, A; Rueff, JCatechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant ...
Three new jatrophane-type diterpenes from Euphorbia pubescens
Valente, C; Ferreira, MJU; Abreu, PM; Pedro, M; Cerqueira, F; Nascimento, MSJThree new macrocyclic jatrophane diterpene polyesters, named pubescenes A (1), B (2), and C (3), and the known compounds indole-3-aldehyde and scopoletin have been isolated and characterised from the whole dried plant of Euphorbia pubescens. The structures of the new compounds were established by spectroscopic means including 2D-NMR techniques such as COSY, HMQC, HMBC and NOESY experiments. Compounds 1-3 were e...
Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of...
Marques, CG; Pedro, M; Simoes, MFA; Nascimento, MSJ; Pinto, MMM; Rodriguez, BFive known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gurke, were evaluated for their in vitro anti proliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. Coleon...
Vaccine against hepatitis B. Eight years of experience.
Marinho, R T; Pedro, M; Ramalho, F; Velosa, J; De Moura, M CHepatitis B virus infection is one of the world's major health problems and health care workers are especially at risk, leading to the need for a high priority vaccination program. Such a program was begun in 1989 in S. Maria Hospital and included all hospital personnel and students of the Faculty of Medicine. The screening included 2360 health care workers and 1153 students. Fifty-five percent of hospital heal...