4 documents found, page 1 of 1
Análise da expressão de genes responsivos à hipóxia em pacientes com anemia fal...
Pedrosa, Alano MartinsHypoxia and hemoglobin S (HbSS) polymerization are the two cardinal triggers responsible for both erythrocyte sickling as well as of all clinical events in sickle cell anemia (SCA), a disease with many pathophysiological and molecular aspects that remain unclear. Despite being a permanent feature of SCA, there is still no consensus on the definition or management of hypoxia in sickle cell patients, and studies ...
Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell ana...
Pedrosa, Alano Martins; Barbosa, Maritza Cavalcante; Santos, Thayna Nogueira dos; Leal, Luzia Kalyne Almeida Moreira; Lopes, Amanda de AraújoA hidroxiuréia (HU) constitui o avanço mais importante no tratamento da anemia falciforme (AF) por prevenir complicações e aumentar a qualidade de vida dos pacientes. Entretanto, alguns aspectos do tratamento com HU permanecem obscuros, incluindo a sua ação e potencial toxicidade em outras células sanguíneas, tais como neutrófilos. Este estudo utilizou a mensuração da lactato desidrogenase (LDH) e do metil tiaz...
Estudo de citotoxicidade, inflamação e estresse oxidativo em neutrófilos de pac...
Pedrosa, Alano MartinsFalciform Anemia (FA) is a hereditary hemoglobinopathy resulting from a β-globin gene mutation (α2β26 GLU→ VAL) that originates a hemoglobin variant called S (HbS). Its polymerization promotes hemolytic and vaso-occlusive crises (VOC). Nowadays it is known that these reactions are initial FA events that unleash a chain reaction that ends with the generation of oxygen reactive types (ORT) nitric oxide (NO) bioav...
Correlation of low levels of nitrite and high levels of fetal hemoglobin in pat...
Elias, Darcielle Bruna Dias; Rocha, Lilianne Brito da Silva; Cavalcante, Maritza Barbosa; Pedrosa, Alano Martins; Justino, Izabel Cristina BandeiraBackground: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers. Objective: To evaluate the correlation of the levels of lactate dehydrogenase, malonaldehyde and nitrite to fetal hemoglobin in patients with sickle cell disease not under treatment with hydroxyurea in o...