Non-alcoholic fatty liver disease (NAFLD), the most predominant liver disease worldwide, is a progressive condition that encompasses a spectrum of disorders ranging from steatosis to steatohepatitis, and, ultimately, cirrhosis and hepatocellular carcinoma. Although the underlying mechanism is complex and multifactorial, several intracellular events leading to its progression have been identified, including oxid...
Introduction: the excessive consumption of fructose can cause liver damage, characteristic of non-alcoholic fatty liver disease (NAFLD) associated with changes in lipid metabolism and antioxidant defenses. Açai, the fruit of Euterpe oleracea Mart., has demonstrated numerous biological activities, including anti-inflammatory, antioxidant, and lipid metabolism modulating action. Objective: we evaluated the benefi...
Objective To study the relationship between exercise and malnourishment because recent evidence suggests that exercise can cause the benefi cial adaptation of antioxidant systems, whereas malnourishment can cause harmful adaptation of these systems. Methods Thirty-two female Fischer rats were equally divided into Sedentary Control, Trained Control, Sedentary Malnourished and Trained Malnourished groups. The tra...
Diabetes mellitus is a metabolic disorder that causes severe complications due to the increased oxidative stress induced by disease. Many plants are popularly used in the treatment of diabetes, e.g., Baccharis trimera (carqueja). The aim of this study was to explore the potential application of the B. trimera hydroethanolic extract in preventing redox stress induced by diabetes and its hypoglycemic properties. ...
Bioactive compounds, present in some foods, act enhancing the endogenous antioxidant system and are proposed as an effective strategy in preventing the changes induced by free radicals in some diseases, such as nonalcoholic fatty liver disease (NAFLD). There has been an increase in the number of studies carried out with the aim of finding natural antioxidant compounds present in fruits, mainly the native fruits...
Aim: To evaluate the surgical procedure and parenchymal abnormalities related to implan-tation of ceramic seeds with holmium-165 in rats’ brain.Background: An effective method of cancer treatment is brachytherapy in which radioactiveseeds are implanted in the tumor, generating a high local dose of ionizing radiation thatcan eliminate tumor cells while protecting the surrounding healthy tissue. BiodegradableHo16...
The goal of this work was to verify whether malnutrition causes modifications in lipid profile and if nutritional recovery associated or not with exercise (swimming, 30 minutes/day, five days/week during 8 weeks) can interfere in this process. Fifty two Fisher female rats were divided into six groups: Control sedentary (CS), control trained (CT), recovered sedentary (RS), malnourished sedentary (MS) and malnour...
The correct characterization of hypercholesterolemic models involves the knowledge of the effect of diet on parameters the go beyond lipid metabolism and that nevertheless reflect the effect of the hypercholesterolemic diet on the development of the animals. Equally important, the exact notion of the magnitude of the stress provoked by physical training helps the understanding of its effect on the objects of in...
The goal of the present work was to study the hepatic function of animals in a process of nutritional recovery associated or not with physical exercise (swimming 30 minutes/day during 8 weeks). Fifty two female Fisher rats were divided into six groups: Control Sedentary (CS), Control Trained (CT), Recovered Sedentary (RS), Recovered Trained (RT), Malnourished Sedentary (MS) and Malnourished Trained (MT). We hav...