7 documents found, page 1 of 1
Growth differentiation factor 15 as a biomarker for risk stratification in the ...
Ferreira, Ricardo; Velho, Tiago R.; Pereira, Rafael Maniés; Pedroso, Dora; Draiblate, Beatriz; Santos, Susana Constantino Rosa; Nobre, AngeloGrowth Differentiation Factor 15 (GDF15) is an emerging biomarker that significantly increases during acute stress responses, such as infections, and is moderately elevated in chronic and inflammation-driven conditions. While evidence suggests that high levels of GDF15 in cardiac surgery are associated with worse outcomes, its utility as an evaluator of early postoperative complications remains unclear. This st...
Role of omega-6 fatty acid metabolism in cardiac surgery postoperative bleeding...
Velho, Tiago R.; Ferreira, Ricardo; Willmann, Katharina; Pedroso, Dora; Paixão, Tiago; Pereira, Rafael Maniés; Junqueira, Nádia; Carvalho Guerra, NunoCardiac surgery is frequently associated with significant postoperative bleeding. Platelet-dysfunction is the main cardiopulmonary bypass (CPB)-induced hemostatic defect. Not only the number of platelets decreases, but also the remaining are functionally impaired. Although lipid metabolism is crucial for platelet function, little is known regarding platelet metabolic changes associated with CPB-dysfunction. Our...
DNA damage independent inhibition of NF-κB transcription by anthracyclines
Pedroso, Dora; Chora, Ângelo Ferreira; Kyriakou, Eleni; Pejanovic, Nadja; Colaço, Henrique; Gozzelino, Raffaella; Barros, André; Willmann, KatharinaAnthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. Here, we show that the extensively used anthracyclines Doxorubicin, Daunorubicin, and Epirubicin decrease the transcription of nuclear factor kappa B (NF-κB)-dependent gene targ...
Deletion of iRhom2 protects against diet-induced obesity by increasing thermoge...
Badenes, Marina; Amin, Abdulbasit; González-García, Ismael; Félix, Inês; Burbridge, Emma; Cavadas, Miguel; Ortega, Francisco José; de Carvalho, ÉrikaObjective: Obesity is the result of positive energy balance. It can be caused by excessive energy consumption but also by decreased energy dissipation, which occurs under several conditions including when the development or activation of brown adipose tissue (BAT) is impaired. Here we evaluated whether iRhom2, the essential cofactor for the Tumour Necrosis Factor (TNF) sheddase ADAM17/TACE, plays a role in the ...
Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Pat...
Moreira, Susana; Rodrigues, Raquel; Barros, André B.; Pejanovic, Nadja; Neves-Costa, Ana; Pedroso, Dora; Pereira, Cláudia; Fernandes, DinaMetabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and...
Changes in expression of the CLOCK gene in obstructive sleep apnea syndrome pat...
Moreira, Susana; Rodrigues, Raquel; Barros, André; Pejanovic, Nada; Neves-Costa, Ana; Pedroso, Dora; Pereira, Cláudia; Fernandes, DinaPurpose: Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS pat...
Anthracyclines induce DNA damage response-mediated protection against severe se...
Figueiredo, Nuno; Chora, Ângelo Ferreira; Raquel, Maria Helena; Pejanovic, Nadja; Pereira, Pedro; Hartleben, Björn; Neves-Costa, Ana; Moita, CatarinaSevere sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options in addition to organ support measures. Here we show that the clinically approved group of anthracyclines acts therapeutically at a low dose regimen to confer robust protection against severe sepsis in mice. This salutary effect is strictly dependent on the activation of DNA damage ...