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Physicochemical characteristics and antiproliferative and antioxidant activitie...

Elamine, Youssef; Lyoussi, Badiaa; Miguel, Maria G.; Anjos, Ofelia; Estevinho, Leticia; Alaiz, Manuel; Giron-Calle, Julio; Martin, Jesus; Vioque, Javier

Zantaz honey is a monofloral variety produced from the melliferous plant Bupleurum spinosum (Apiaceae), a shrub that grows mainly in the Atlas Moroccan Mountains. Determination of the polyphenol composition revealed that methyl syringate accounts for more than 50% of total polyphenols, which represents a very useful parameter for the characterization of this monofloral honey. Epicatechin, syringic acid and cate...


High-content screening of natural products reveals novel nuclear export inhibitors

Cautain, Bastien; de Pedro, Nuria; Garzon, Virginia Murillo; de Escalona, Maria Munoz; Menendez, Victor Gonzalez; Tormo, Jose R.; Martin, Jesus

Natural products are considered an extremely valuable source for the discovery of new drugs against diverse pathologies. As yet, we have only explored a fraction of the diversity of bioactive compounds, and opportunities for discovering new natural products leading to new drugs are huge. In the present study, U2nesRELOC, a previously established cell-based imaging assay, was employed to screen a collection of e...


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