7 documents found, page 1 of 1

Real-World Effectiveness and Safety of Glecaprevir/Pibrentasvir for the Treatme...

Introduction: Information about pan-genotypic treatments for hepatitis in Portugal is scarce. We aimed to evaluate the effectiveness and safety of glecaprevir plus pibrentasvir (GLE/PIB) treatment for hepatitis C virus (HCV) infection in real-world clinical practice.Methods: An observational prospective study was implemented in six hospitals with 121 adult HCV patients who initiated treatment with GLE/PIB betwe...

Colorectal Screening Program in Northern Portugal: First Findings

Introduction: In Portugal, a colorectal cancer screening program based on faecal immunochemical test followed by colonoscopy was shown to be cost-effective for individuals between 50 and 74 years old. We report the first findings of the implementation of a population-based program In Northern Portugal.Material and Methods: In the pilot phase, eligible subjects were allocated either to a direct mailing invitatio...

Correction to the article “Colorectal Screening Program in Northern Portugal: F...

On page 168, Table 2, where it reads:On page 168, Table 2, where it reads:Advanced phenotype rate* [n (%)] 35 (49.0) 10 (52.0) 25 (47.0) 0.606Carcinoma** [n (%)] 2 (2.0) 1 (5.0) 1 (2.0)It should read:Advanced phenotype rate [n (%)] 179 (22.0) 57 (30.0) 35 (21.0) 29 (21.0) 24 (14.0) 34 (24.0)Carcinoma [n (%)] 3 (0.4) 2 1On page 168, Table 3, where it reads:ADR (%) 80.0 -Advanced adenoma (%) 44.0 15.9It should re...

Predictors for incomplete response to ursodeoxycholic acid in primary biliary c...

Background: The current standard of treatment in primary biliary cholangitis (PBC) is ursodeoxycholic acid (UDCA), although a considerable proportion of patients show incomplete response resulting in disease progression. Objective: This study aimed to assess the prevalence of incomplete response to UDCA and determine associated patients' characteristics. Methods: Patients with PBC as main diagnosis were include...

Metabolic control of T cell immune response through glycans in inflammatory bow...

Mucosal T lymphocytes from patients with ulcerative colitis (UC) were previously shown to display a deficiency in branched N-glycosylation associated with disease severity. However, whether this glycosylation pathway shapes the course of the T cell response constituting a targeted-specific mechanism in UC remains largely unknown. In this study, we demonstrated that metabolic supplementation of ex vivo mucosal T...

Successfull endoscopic closure of gastrocutaneous fistula with an over-the-scop...

Health systems organization for emergency care

The increasing number of acute and severe digestive diseases presenting to hospital emergency departments, mainly related with an ageing population, demands an appropriate answer from health systems organization, taking into account the escalating pressure on cost reduction. However, patients expect and deserve a response that is appropriate, effective, efficient and safe. The huge variety of variables which ca...