2 documents found, page 1 of 1
β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis
Silva, AM; Chan, FY; Norman, MJ; Sobral, AF; Zanin, E; Gassmann, R; Belmonte, JM; Carvalho, AXCytokinesis requires the constriction of an actomyosin-based contractile ring and involves multiple F-actin crosslinkers. We show that partial depletion of the C. elegans cytokinetic formin generates contractile rings with low F-actin levels that constrict but are structurally fragile, and we use this background to investigate the roles of the crosslinkers plastin/PLST-1 and β-heavy-spectrin/SMA-1 during ring c...
Equatorial Non-muscle Myosin II and Plastin Cooperate to Align and Compact F-ac...
Leite, J; Chan, FY; Osório, DS; Saramago, J; Sobral, AF; Silva, AM; Gassmann, R; Carvalho, AXCytokinesis is the last step of cell division that physically partitions the mother cell into two daughter cells. Cytokinesis requires the assembly and constriction of a contractile ring, a circumferential array of filamentous actin (F-actin), non-muscle myosin II motors (myosin), and actin-binding proteins that forms at the cell equator. Cytokinesis is accompanied by long-range cortical flows from regions of r...