13 documents found, page 1 of 2
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker trigger...
Peixoto, A; Ferreira, D; Azevedo, R; Freitas, R; Fernandes, E; Relvas-Santos, M; Gaiteiro, C; Soares, J; Cotton, S; Teixeira, B; Paulo, P; Lima, LBackground: Muscle invasive bladder cancer (MIBC) remains amongst the deadliest genitourinary malignancies due to treatment failure and extensive molecular heterogeneity, delaying effective targeted therapeutics. Hypoxia and nutrient deprivation, oversialylation and O-glycans shortening are salient features of aggressive tumours, creating cell surface glycoproteome fingerprints with theranostics potential. Meth...
Target score—a proteomics data selection tool applied to esophageal cancer iden...
Cotton, S; Ferreira, D; Soares, J; Peixoto, A; Relvas-Santos, M; Azevedo, R; Piairo, P; Diéguez, L; Palmeira, C; Lima, L; Silva, AMN; Santos, LLEsophageal cancer (EC) is a life-threatening disease, demanding the discovery of new biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins hold tremendous potential towards this objective. In the current study, a series of esophageal squamous cell carcinomas (ESCC) and EC-derived circulating tumor cells (CTCs) were screened by immunoassays for the sialyl-Tn (STn) antigen, a g...
Nucleolin-sle a glycoforms as E-selectin ligands and potentially targetable bio...
Fernandes, E; Freitas, R; Ferreira, D; Soares, J; Azevedo, R; Gaiteiro, C; Peixoto, A; Oliveira, S; Cotton, S; Relvas-Santos, M; Afonso, LP; Palmeira, CBackground: Gastric cancer (GC) is a major health burden worldwide, with half of patients developing metastases within 5 years after treatment, urging novel biomarkers for diagnosis and efficient therapeutic targeting. Sialyl-Lewis A (SLeA), a terminal glycoepitope of glycoproteins and glycolipids, offers tremendous potential towards this objective. It is rarely expressed in healthy tissues and blood cells, whi...
Esophageal, gastric and colorectal cancers: Looking beyond classical serologica...
Fernandes, E; Sores, J; Cotton, S; Peixoto, A; Ferreira, D; Freitas, R; Reis, CA; Santos, LL; Ferreira, JAEsophageal (OC), gastric (GC) and colorectal (CRC) cancers are amongst the digestive track tumors with higher incidence and mortality due to significant molecular heterogeneity. This constitutes a major challenge for patients’ management at different levels, including non-invasive detection of the disease, prognostication, therapy selection, patient’s follow-up and the introduction of improved and safer therape...
Tumor Testing for Somatic and Germline BRCA1/BRCA2 Variants in Ovarian Cancer P...
Peixoto, A; Pinto, P; Guerra, J; Pinheiro, M; Santos, C; Pinto, C; Santos, R; Escudeiro, C; Bartosch, C; Canário, R; Barbosa, A; Gouveia, A; Petiz, ADeleterious variants in the BRCA1/BRCA2 genes and homologous recombination deficiency (HRD) status are considered strong predictors of response to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi). The introduction of PARPi in clinical practice for the treatment of patients with advanced ovarian cancer imposed changes in the molecular diagnosis of BRCA1/BRCA2 variants. BRCA1/BRCA2 tumor testing by next-gen...
Protein glycosylation and tumor microenvironment alterations driving cancer hal...
Peixoto, A; Relvas-Santos, M; Azevedo, R; Santos, LL; Ferreira, JADecades of research have disclosed a plethora of alterations in protein glycosylation that decisively impact in all stages of disease and ultimately contribute to more aggressive cell phenotypes. The biosynthesis of cancer-associated glycans and its reflection in the glycoproteome is driven by microenvironmental cues and these events act synergistically toward disease evolution. Such intricate crosstalk provide...
CD44 glycoprotein in cancer: A molecular conundrum hampering clinical applications
Azevedo, R; Gaiteiro, C; Peixoto, A; Relvas-Santos, M; Lima, L; Santos, L; Ferreira, JACD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently explored for stem cell identification, and associated with chemoresistance and metastasis. However, CD44 is a general designation for a large family of splicing variants exhibiting different degrees of glyco...
Cancer Survivor Study (CASUS) on colorectal patients: longitudinal study on phy...
Soares-Miranda, L; Abreu, S; Silva, M; Peixoto, A; Ramalho, R; da Silva, PC; Costa, C; Teixeira, JP; Gonçalves, C; Moreira, P; Mota, J; Macedo, GPurpose: Evidence suggests that being physically active in combination with a healthy diet contributes to diminish colorectal cancer risk. However, if this is true for colorectal cancer primary prevention, the same is not clear for its recurrence after colorectal cancer treatments. Data on cancer survival are scarce, and there is a need for greater attention on these survivors’ lifestyle behavior. This manuscri...
Association between Polymorphisms in Antioxidant Genes and Inflammatory Bowel D...
Pereira, CC; Durães, C; Coelho, R; Grácio, D; Silva, M; Peixoto, A; Lago, P; Pereira, M; Catarino, T; Pinho, S; Teixeira, JP; Macedo, G; Annese, VInflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Croh...
DNA damage and oxidative DNA damage in Inflammatory Bowel Disease
Pereira, C; Coelho, R; Grácio, D; Dias, C; Silva, M; Peixoto, A; Lopes, P; Costa, C; Teixeira, JP; Macedo, G; Magro, FBACKGROUND AND AIMS:Inflammation has long been regarded as a major contributor to cellular oxidative damage and to be involved in the promotion of carcinogenesis. METHODS:We aimed to investigate the oxidative damage in inflammatory bowel disease [IBD] patients through a case-control and prospective study involving 344 IBD patients and 294 healthy controls. DNA damage and oxidative DNA damage were measured by co...