6 documents found, page 1 of 1
HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...
Andrade, Rita; Perez-Rojas, Judith; da Silva, Sílvia Gomes; Miskinyte, Migla; Quaresma, Margarida C; Frazão, Laura P; Peixoto, CarolinaBackground/objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable access to care. This study aims to enhance pa...
HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...
Andrade, Rita; Pérez, Judith; da Silva, Sílvia Gomes; Miskinyte, Migla; Quaresma, Margarida C.; Frazão, Laura P.; Peixoto, Carolina; Cubells, AlmudenaPublisher Copyright: © 2025 by the authors.; Background/Objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable ...
Expression profiling in ovarian cancer reveals coordinated regulation of BRCA1/...
Custódio, Noélia; Savisaar, Rosina; Carvalho, Célia; Bak-Gordon, Pedro; Ribeiro, Maria I.; Almeida-Tavares, Joana; Nunes, Paula B.; Peixoto, CarolinaPredictive biomarkers are crucial in clarifying the best strategy to use poly(ADP-ribose) polymerase inhibitors (PARPi) for the greatest benefit to ovarian cancer patients. PARPi are specifically lethal to cancer cells that cannot repair DNA damage by homologous recombination (HR), and HR deficiency is frequently associated with BRCA1/2 mutations. Genetic tests for BRCA1/2 mutations are currently used in the cl...
TCox : correlation-based regularization applied to colorectal cancer survival data
Peixoto, Carolina; Lopes, Marta B.; Martins, Marta; Costa, Luis; Vinga, SusanaColorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. Being a heterogeneous disease, cancer therapy and prognosis represent a significant challenge to medical care. The molecular information improves the accuracy with which patients are classified and treated since similar pathologies may show different clinical outcomes and other responses to treatment. However, the high...
Dos traumas da (des)colonização ao mal-estar nas relações político-económicas a...
Peixoto, Carolina; Vasile, IolandaQuarenta anos depois do fim do império português os impactos e latências políticas, culturais e epistémicas da forma como se deu a transição para a independência de Angola continuam a influenciar as relações entre este país e Portugal. Considerando a descolonização enquanto um fenómeno social complexo movido pelo questionar do impacto das relações de violência e exploração vivenciadas durante a colonização (Men...
Por uma perspectiva histórica pós-colonial, um estudo de caso: a ʻdescolonizaçã...
Peixoto, CarolinaUma análise crítica da pós-colonialidade requer um exame do processo de memória seletiva e esquecimento nas antigas sociedades coloniais. Considerando que a descolonização deveria corresponder a um questionamento do impacto das relações de violência e exploração vivenciadas durante a colonização, parece plausível afirmar que, apesar de concretizada a transição política que permitiu que Angola se tornasse um Est...