5 documents found, page 1 of 1
Development and in vitro assessment of injectable, adhesive, and self-healing c...
Correia, Cátia Sofia Palma; Peixoto, D.; Soares da Costa, Diana; Reis, R. L.; Pashkuleva, I.; Alves, N. M.Injured spinal cords have a limited ability to regenerate because of the inhibitory environment formed in situ that affects neuronal regrow. Ensuring stable contact between the injuried nerves to support neural regeneration in the lesion microenvironment remains a significant challenge. To address this challenge, we have engineered a new injectable and adhesive hydrogel to treat spinal cord injuries. This hydro...
Adhesive and antibacterial films based on marine-derived fucoidan and chitosan
Correia, C.; Costa, Diana Pereira Soares; Inácio, A. R.; Vale, A. C.; Peixoto, D.; Silva, Tiago H.; Reis, R. L.; Pashkuleva, I.; Alves, N. M.Marine-derived polymers are environmentally friendly and sustainable biomaterials that have structural similarities with the main components of the extracellular matrix. Moreover, some marine polymers have specific bioactivity that can be transferred to the systems made of these biomolecules. Herein, we developed antibacterial adhesive films combining two marine polysaccharides, namely, fucoidan and chitosan. F...
THE ROLE OF CHOLINESTERASES IN ALZHEIMER’S DISEASE: SCREENING OF TARGET COMPOUNDS
Bacalhau, P.; San Juan, A.; Marques, C.; Peixoto, D.; Burke, A.; Caldeira, A. T.; Martins, M. R.Background: Alzheimer's disease (AD) is the most common form of dementia and causes a progressive and irreversible neurodegeneration. The loss of cholinergic neurons leads to the progressive reduction of acetylcholine (ACh) in the brain and resulting cognitive impairment in AD. ACh is hydrolyzed by both acetylcholinesterase (AChE) and butirylcholinesterase (BuChE). It was found that in the course of the disease...
Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-Aryl-...
Machado, Vera A.; Peixoto, D.; Costa, R.; Froufe, H. J. C.; Calhelha, Ricardo C.; Abreu, R. M. V; Ferreira, Isabel C. F. R.; Soares, R.The synthesis and biological evaluation of novel 1-aryl-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas 3, 4 and 5 as VEGFR-2 tyrosine kinase inhibitors, are reported. The 1-aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas 4a-4h, with the arylurea in the meta position to the thioether, showed the lowest IC50 values in enzymatic assays (10-206 nM), the most potent compounds 4d-4h (IC50 10-28 nM) ...
Recurrent focal myositis: a rare inflammatory myopathy
Teixeira, F.; Peixoto, D.; Costa, J.; Bogas, M.; Taipas, R.; Melo-Pires, M.; Afonso, C.; Araújo, D.Focal myositis is an acute and localized muscle inflammation of unknown aetiology. The clinical diagnosis is often difficult to obtain, since it can be confused with infections, vascular thrombosis or muscle tumours such as sarcomas. This leads to a significant delay in the diagnosis, resulting in the administration of inappropriate and potentially harmful treatments. We report here a case of recurrent focal my...