8 documents found, page 1 of 1
A Reproducible Workflow for Macrophage Membrane Isolation and Nanocore Selectio...
Peixoto, Diana; Diaz-Rodriguez, Patricia; Veiga, Francisco; Concheiro, Angel; Paiva-Santos, Ana Cláudia; Conde, João; Alvarez-Lorenzo, CarmenMacrophage membrane–coated nanoparticles (M2M-NPs) offer a promising strategy for targeting immunologically “cold” tumors resistant to conventional therapies. However, workflows for membrane isolation and NP coating remain limited and often lack reproducibility. Herein, a multi-step process was established for isolating plasma membranes from human M2-like macrophages. This optimized workflow combines hypotonic ...
Exosome membrane-coated nanosystems: Exploring biomedical applications in cance...
Shao, Minmin; Lopes, Daniela; Lopes, Joana; Yousefiasl, Satar; Macário-Soares, Ana; Peixoto, Diana; Ferreira-Faria, Inês; Veiga, Francisco; Conde, JoãoBio-mimicking principles have recently been proposed for the surface functionalization of nanoparticles (NPs). Such a strategy is based on camouflaging the NP surface with functional biomembranes to render superior biocompatibility, interfacial features, immune evasion, and active targeting properties to nanomaterials. In this area of research, cell membranes derived from a plethora of highly optimized cells, s...
Liposome-based diagnostic and therapeutic applications for pancreatic cancer
Raza, Faisal; Evans, Lauren; Motallebi, Mahzad; Zafar, Hajra; Pereira-Silva, Miguel; Saleem, Kalsoom; Peixoto, Diana; Rahdar, Abbas; Sharifi, EsmaeelPancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled as incurable. Chemotherapy continues to be the most popular treatment yet yields a very poor prognosis. The main barriers such as inefficient drug penetration and drug resistance, have led to the development of drug car- rier systems. The benefits, ease of fabrication and modification of liposomes render them as ideal ...
Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenera...
Lopes, Daniela; Lopes, Joana; Pereira-Silva, Miguel; Peixoto, Diana; Rabiee, Navid; Veiga, Francisco; Moradi, Omid; Guo, Zhan-Hu; Wang, Xiang-DongA bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This strategy endows cloaked nanomaterials with improved interfacial properties, superior cell targeting, immune evasion potential, and prolonged duration of systemic circulation. Here, we summarize recent advances in the production and a...
Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems
Paiva-Santos, Ana Cláudia; Gonçalves, Tatiana; Peixoto, Diana; Pires, Patrícia C.; Velsankar, K.; Jha, Niraj Kumar; Chavda, Vivek P.Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, and phymatous alterations accompanied by itching, burning, or stinging, the pathophysiology of which is not yet fully understood. Conventional topical treatments usually show limited efficacy due to the physical barrier property of the skin that hinders skin penetra...
Nano- and microparticle-stabilized Pickering emulsions designed for topical the...
Peito, Sofia; Peixoto, Diana; Ferreira-Faria, Inês; Martins, Ana Margarida; Ribeiro, Helena; Veiga, Francisco; Marto, Joana; Paiva-Santos, Ana CláudiaPickering emulsions are systems composed of two immiscible fluids, which are stabilized by solid organic or inorganic particles. These solid particles include a broad range of particles that can be used to stabilize Pickering emulsions. An improved resistance against coalescence and lower toxicity, against conventional emulsions stabilized by surfactants, make Pickering emulsions suitable candidates for numerou...
Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia
Santos, Ana Cláudia; Silva, Miguel Pereira da; Guerra, Catarina; Costa, Diana; Peixoto, Diana; Pereira, Irina; Pita, Inês R.; Ribeiro, António J.Androgenetic alopecia (AGA) is a multifactorial and age-related condition characterized by substantial hair loss a ecting both men and women. Conventional treatments include the use of topical minoxidil (MNX) formulations to stimulate hair growth and restore hair condition. However, those treatments are associated with limited performance and a lack of tolerability and compliance due to the emergence of adverse...
Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin fo...
Pires, Patrícia C.; Peixoto, Diana; Teixeira, Isaura; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.Phenytoin is a low solubility anticonvulsant drug. It has, nonetheless, other possible therapeutic indications, such as neuropathic pain, including trigeminal neuralgia, or wound healing. Its use has decreased due to side effects, but nasal/intranasal administration could significantly increase drug safety and efficacy. The aim of this work was to develop and study nanoemulsions and thermosensitive nanoemulgels...