25 documents found, page 1 of 3
The role of natural compounds in rat mammary cancer: the beneficial effects of ...
Azevedo, Tiago; Silva, Jessica; Peixoto, Francisco P.; Silvestre-Ferreira, Ana C.; Gama, Adelina; Seixas, Fernanda; Finimundy, Tiane C.; Barros, LillianBreast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, including anticancer and anti-diabetic properties. This study aimed to assess the chemopreventive effects of S. chamaecyparissus aqueous extract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were divid...
Interplay Between Western Diet and Mammary Cancer: Data from a Chemically-induc...
Silva, Jessica; Aires, Inês; Peixoto, Francisco P.; Neuparth, Maria João; Queiroga, Felisbina; Seixas, Fernanda; Ferreira, Rita; Faustino-Rocha, AnaThis study aimed to investigate the influence of Western diet on mammary cancer in Wistar female rats, focusing on systemic responses and tumor development. Materials and Methods: Twenty-eight Wistar female rats were acclimatized and divided into four experimental groups (n=7 each): Western diet (WD), Western diet with N-methyl-N-nitrosourea (MNU) administration (WD+MNU), standard diet (CTR), and standard diet ...
Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: pr...
Gonçalves, Sara; Peixoto, Francisco P.; Silveira, Tayse F. F. da; Barros, Lillian; Gaivão, IsabelThe integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress and accelerate ageing. The demand for natural and organic cosmetics is rising due to the harmful effects of synthetic genotoxic agents on human health and the environment. Elderberry (Sambucus nigra L.), a fruit rich in bioactive compounds such as polyphenols, has demonstrated significant...
Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...
Medeiros, Catarina; Silva, Ana Rita; Ferreira, Tiago; Barros, Lillian; Neuparth, Maria João; Peixoto, Francisco P.; Bastos, Margarida M.S.M.Infections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic com...
The influence of Castanea sativa Mill. flower extract on hormonally and chemica...
Nascimento-Gonçalves, Elisabete; Seixas, Fernanda; Silva, Marcelo Aparecido de Souza; Fardilha, Margarida; Ferreira, Rita; Neuparth, Maria JoãoProstate cancer (PCa) is one of the most common cancers in men, with a huge impact on their health. The use of Castanea sativa Mill. flowers (CFs) in beverages has been reported, through ancestral claims, as having health benefits. In vitro research has evidenced the properties of CFs, such as antitumor and antioxidant activities. This study aimed to evaluate the effects of CF extract in an animal model of PCa....
The cyclooxigenase-2 inhibitor parecoxib prevents epidermal dysplasia in HPV16-...
Ferreira, Tiago; Campos, Sandra; Silva, Mónica; Ribeiro, Rita; Santos, Susana; Almeida, José L.S.; Pires, Maria João; Costa, Rui Miguel GilCarcinogenesis induced by high-risk human papillomavirus (HPV) involves inflammatory phenomena, partially mediated by cyclooxigenase-2. In pre-clinical models of HPV-induced cancer, cyclooxygenase-2 inhibitors have shown significant e cacy, but also considerable toxicity. This study addresses the chemopreventive e ect and hepatic toxicity of a specific cyclooxigensase-2 inhibitor, parecoxib, in HPV16-transgenic...
The effects of long-term chaetomellic acid a administration on renal function a...
Nogueira, António José M.; Peixoto, Francisco P.; Oliveira, Maria Manuel; Pires, Carlos André; Colaço, Bruno Jorge; Oliveira, Paula A.This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in amodel of renalmass reduction. Methods.MaleWistar ratswere subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n = 14); RMR + CAA: RMR rats treated with CAA (n = 1...
Toxicological evaluation and polyphenols characterization of pterospartum tride...
Ferreira, Fernanda M.; Peixoto, Francisco P.; Pereira, Olívia R.; Dinis, Lia Tânia; Domingues, Maria R.M.; Palmeira, Carlos M.; Cardoso, Susana M.Pterospartum tridentatum Willk. (prickled broom) is a common autochthonous plant in Portugal. Leaves and stems are normally used in cooking, to flavour rice, roast meat or hunting animals. Leaves are also used as a condiment in fresh salads and, despite of its traditional use, no toxicological evaluation has been performed. P. tridentatum leaves aqueous extract ESI-MS spectrum revealed the presence of several l...
Toxicological evaluation and polyphenols characterization of pterospartum tride...
Ferreira, Fernanda M.; Peixoto, Francisco P.; Pereira, Olívia R.; Dinis, Lia Tânia; Domingues, Maria R.M.; Palmeira, Carlos M.; Cardoso, Susana M.Pterospartum tridentatum Willk. (prickled broom) is a common autochthonous plant in Portugal. Leaves and stems are normally used in cooking, to flavour rice, roast meat or hunting animals. Leaves are also used as a condiment in fresh salads and, despite of its traditional use, no toxicological evaluation has been performed. P. tridentatum leaves aqueous extract ESI-MS spectrum revealed the presence of several l...
Polyphenols characterization and toxicological evaluation of pterospartum tride...
Ferreira, Fernanda M.; Peixoto, Francisco P.; Pereira, Olívia R.; Dinis, Lia Tânia; Domingues, Maria R.M.; Palmeira, Carlos M.; Cardoso, Susana M.Pterospartum tridentatum Willk. (prickled broom) is an autochthonous and common plant in Portugal. Leaves and stems are normally used in cooking, to flavour rice, roast meat or hunting animals. Leaves are also used as a condiment in fresh salads and, despite of its traditional use, no toxicological evaluation has been performed. P. tridentatum leaves aqueous extract ESI-MS spectrum revealed the presence of seve...