Background: Pain is one of the most common and debilitating symptoms among cancer patients, significantly impacting their quality of life. Effective management of cancer pain is challenging due to its varying intensity and characteristics, making it a public health priority. Recently, neuromodulation techniques, such as Transcranial Magnetic Stimulation (TMS) and Transcranial Direct Current Stimulation (tDCS), ...
The global incidence of oncological disease is rising, driven by increased longevity and greater exposure to carcinogens. Pain remains one of the most prevalent and disabling symptoms among cancer patients, requiring urgent evaluation and treatment. However, selecting an effective therapeutic approach remains a challenge. Neuromodulation techniques such as Transcranial Magnetic Stimulation (rTMS) and Transcrani...
Thyroid cancer(TC) is the most common endocrine malignancy, arising from follicular and parafollicular cells. Oxidative stress, caused by excess reactive oxygen species(ROS) and metabolites, influences TC development and progression, as the thyroid is highly exposed to ROS. The redox balance is maintained by antioxidant enzymes (SOD, GPX) and non-enzymatic antioxidants, which limit ROS formation and detoxify me...
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Cancer stem cells (CSCs) are relevant therapeutic targets for cancer treatment. Still, the molecular circuits behind CSC characteristics are not fully understood. The low number of CSCs can sometimes be an obstacle to carrying out assays that explore their properties. Thus, increasing CSC numbers via small molecule-mediated cellular reprogramming appears to be a valid alternative tool. Using the SORE6-GFP repor...
Glioblastoma (GB) is a deadly tumor that demands for relevant biomarkers, particularly regarding patients’ response to treatment. MMP-2, MMP-9, VEGFA, and YKL40 are important molecules, given their implication in the infiltrative and angiogenic phenotype of GBs. The purpose of this study was to assess the relationship between the expression of MMP-2, MMP-9, VEGFA, and YKL40 in GB tissues and the patients’ respo...
Introduction: Acne is an extremely prevalent condition. The healing of active acne lesions may result in the development of scars. Atrophic scars are the main scars caused by acne and result from the degradation of collagen fibers. Carboxytherapy is a minimally invasive method that involves the application of carbon dioxide subcutaneously through small infiltrations in the skin, which improves scar tissue by in...
O presente documento visa a apresentação, de forma sistematizada, de um Modelo de Governação, cujo objetivo é o de providenciar funções e responsabilidades, processos e ferramentas que ajudem a garantir a governação dos Programas e Projetos desenvolvidos em contexto colaborativo entre Universidade-Industria (UI), no âmbito de programas de financiamento. O principal objetivo do Modelo de Governanção é garantir o...
This paper describes the results of a qualitative study to identify the key management initiatives in a successful university-industry (UI) collaborative funded program between the University of Minho (UMinho) and Bosch Car Multimedia Portugal (Bosch), named IC-HMI. The IC-HMI program embraced an overall investment of 54.7 M€ and involved around 500 people throughout the Program's duration (2015-2018). While th...
No âmbito do Projeto Othukumana – Juntos. Reforço das capacidades da rede diocesana católica de ensino pré-escolar, da responsabilidade da Diocese do Niassa, em Moçambique, e em parceria com a Fundação Fé e Cooperação, Leigos para o Desenvolvimento e Escola Superior de Educação de Paula Frassinetti, foi desenvolvido um estudo de caracterização das Escolinhas Comunitárias da Província do Niassa, em Moçambique. O...