2 documents found, page 1 of 1
Hematopoiesis: A Layered Organization Across Chordate Species
Elsaid, R; Soares-da-Silva, F; Peixoto, M; Amiri, D; Mackowski, N; Pereira, P; Bandeira, A; Cumano, AThe identification of distinct waves of progenitors during development, each corresponding to a specific time, space, and function, provided the basis for the concept of a “layered” organization in development. The concept of a layered hematopoiesis was established by classical embryology studies in birds and amphibians. Recent progress in generating reliable lineage tracing models together with transcriptional...
Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Develo...
Soares-da-Silva, F; Peixoto, M; Cumano, A; Pinto-do-Ó, PHematopoietic stem cells (HSCs) generated during embryonic development are able to maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC transplantation is a widely used cell therapy intervention in the treatment of hematologic, autoimmune and genetic disorders. Its use, however, is hampered by the inability to expand HSCs ex vivo, urging for a better understanding of the mechanisms ...