6 documents found, page 1 of 1
Evaluation of the impact of two C5 genetic variants on C5-eculizumab complex st...
Peixoto, Vanda; Prudêncio, Cristina; Vieira, Mónica; Sousa, Sérgio F.Complement C5 is the target of the monoclonal antibody eculizumab, used in complement dysregulating disorders, like the rare disease Paroxysmal Nocturnal Hemoglobinuria (PNH). PNH is an acquired hematopoietic stem cell condition characterized by aberrant destruction of erythrocytes, chronic hemolytic anemia, and thromboembolism propensity. C5 is a protein component of the complement system which is part of the ...
Exploring treatment strategies for paroxysmal nocturnal hemoglobinuria: an over...
Peixoto, Vanda; Prudêncio, Cristina; Vieira, MónicaParoxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease in which blood cells lack anchored proteins that regulate the complement system. The erythrocytes are then destroyed because of uncontrolled complement activity, leading to intravascular hemolysis (IVH) and a high risk of thrombosis outcome. A huge alteration in the treatment of the disease was the development of terminal complement inhibitor...
Paroxysmal nocturnal hemoglobinuria: a case report in a pandemic environment
Peixoto, Vanda; Carneiro, Ana; Trigo, Fernanda; Vieira, Mónica; Prudêncio, CristinaParoxysmal nocturnal hemoglobinuria (PNH) is a clonal, rare, complement-mediated hemolytic anemia. PNH can be associated with marrow failure and thrombophilia. We present a clinical report of splenic vein thrombosis in a patient with classic PNH. A 41-year-old male with classic PNH, naïve to complement inhibitor therapy, developed splenic vein thrombosis as a major adverse effect after vaccination protocol to p...
Mechanisms of paroxysmal nocturnal hemoglobinuria clonal expansion
Peixoto, Vanda; Vieira da Silva, Manuela; Prudêncio, CristinaParoxysmal Nocturnal Hemoglobinuria (PNH) is a rare, acquired clonal disease of bone marrow stem-cells, genetically characterized by the somatic mutation of the phosphatidylinositol glycan class A (PIG-A) gene. That leads to defective synthesis of glycosylphosphatidylinositol (GPI) responsible for anchorage and fixation of surface proteins like complement decay-accelerating factor (DAF/CD55) and membrane inhibi...
Relação entre os hábitos alimentares e actividade física com o excesso de peso ...
Prudêncio, Cristina; Dores, Artemisa Rocha; Fernandes, Ruben; Peixoto, Vanda; Pereira, Ana Cláudia; Borges, CristinaA obesidade é uma patologia que tem aumentado drasticamente nos últimos anos, sendo que a mesma se tem manifestado de forma particularmente assustadora em crianças e adolescentes.
Avaliação do stress oxidativo na disfunção erétil
Peixoto, VandaAs sequelas fisiopatológicas do stress oxidativo são difíceis de quantificar. Apesar dos obstáculos, a relevância médica do stress oxidativo tem vindo a ser cada vez mais reconhecida, sendo hoje em dia encarado como um componente chave de virtualmente todas as doenças. A disfunção erétil (DE) surge neste contexto como uma espécie de barómetro da função endotelial e do dano oxidativo. A quantificação de biomarca...