17 documents found, page 1 of 2
Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, ...
Pinello, Katia; Pires, Isabel; Castro, Ana Filipa; Carvalho, Paulo Tiago; Santos, Andreia; Matos, Augusto; Queiroga, Felisbina; Canadas-Sousa, AnaThe animal cancer burden is essential for the translational value of companion animals in comparative oncology. The present work aims to describe, analyze, and compare frequencies and associations of tumors in dogs and cats based on the Animal Cancer Registry created by Vet-OncoNet. With 9079 registries, regarding 2019 and 2020, 81% (n = 7355) belonged to dogs. In comparison, cats have a general one-year right ...
Vet-OncoNet: Malignancy Analysis of Neoplasms in Dogs and Cats
Pinello, Katia; Amorim, Irina; Pires, Isabel; Canadas-Sousa, Ana; Catarino, José; Faísca, Pedro; Branco, Sandra; Peleteiro, Maria C.; Silva, DanielaAnalysis of canine and feline tumor malignancy data can help clinicians identify high-risk patients and make more accurate decisions. Based on a sample of 16,272 cancer records, including 3266 cats and 13,006 dogs, collected from January 2019 to December 2021 in the Vet-OncoNet Network database, this study aimed to compare the tumor malignancy profile between cats and dogs, considering animal-related factors (s...
Mitochondrial genetic diversity, selection and recombination in a canine transm...
Strakova, Andrea; Leathlobhair, Máire Ní; Wang, Guo-Dong; Yin, Ting-Ting; Airikkala-Otter, Ilona; Allen, Janice L.; Allum, Karen M.Made available in DSpace on 2022-04-28T19:03:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-05-17; Leverhulme Trust; Wellcome Trust; Royal Society; Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been a...
Evaluation of commercial myxomatosis vaccines against recombinant myxoma virus ...
Abade Dos Santos, F.A.; Carvalho, Carina; Valente, Pamela; Armes, Henrique; Reemers, Sylvia S.; Peleteiro, Maria C.; Calonge Sanz, InesThe recent emergence of a new myxoma virus capable of causing disease in the Iberian hare (Lepus granatensis) has resulted in numerous outbreaks with high mortality leading to the reduction, or even the disappearance, of many local populations of this wild species in the Iberian Peninsula. Currently, the available vaccines that prevent myxomatosis in domestic rabbits caused by classic strains of myxoma virus ha...
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit
Abade Dos Santos, F.A.; Magro, Carolina; Carvalho, Carina L.; Ruivo, Pedro; Duarte, Margarida D.; Peleteiro, Maria C.ABSTRACT - Rabbit haemorrhagic disease (RHD) is a highly contagious infectious disease of European wild and domestic rabbits. Rabbit haemorrhagic disease virus (RHDV, GI.1) emerged in 1986 in Europe, rapidly spreading all over the world. Several genotypes of RHDV have been recognised over time, but in 2010, a new virus (RHDV2/RHDVb, GI.2) emerged and progressively replaced the previous RHDV strains, due to the ...
A versatile qPCR for diagnosis of leporid gammaherpesvirus 5 using Evagreen® or...
Abade Dos Santos, F.A.; Carvalho, Carina L.; Peleteiro, Maria C.; Parra, Francisco; Duarte, M. D.ABSTRACT - In late 2019, the first herpesvirus in the genus Lepus, named leporid gammaherpesvirus 5 (LeHV-5) was described. At the time, herpetic typical lesions were observed in hares infected by the myxoma virus, which is known to induce immunosuppression. Though the real impact of LeHV-5 is still poorly understood, since it affects reproduction, it poses an additional threat to the already fragile population...
A quadruplex qPCR for detection and differentiation of classic and natural reco...
Abade Dos Santos, F.A.; Carvalho, Carina L.; Francisco, Parra; Dalton, Kevin P.; Peleteiro, Maria C.; Duarte, M. D.A natural recombinant myxoma virus (referred to as ha-MYXV or MYXV-Tol08/18) emerged in the Iberian hare (Lepus granatensis) and the European rabbit (Oryctolagus cuniculus) in late 2018 and mid-2020, respectively. This new virus is genetically distinct from classic myxoma virus (MYXV) strains that caused myxomatosis in rabbits until then, by acquiring an additional 2.8 Kbp insert within the m009L gene that disr...
Recurrent horizontal transfer identifies mitochondrial positive selection in a ...
Strakova, Andrea; Nicholls, Thomas J.; Baez-Ortega, Adrian; Ní Leathlobhair, Máire; Sampson, Alexander T.; Hughes, Katherine; Bolton, Isobelle A. G.Made available in DSpace on 2020-12-12T01:27:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations hav...
A potential atypical case of rabbit haemorrhagic disease in a dwarf rabbit
Abade dos Santos, Fábio A.; Magro, Carolina; Carvalho, Carina L.; Ruivo, Pedro; Duarte, Margarida D.; Peleteiro, Maria C.Rabbit haemorrhagic disease (RHD) is a highly contagious infectious disease of European wild and domestic rabbits. Rabbit haemorrhagic disease virus (RHDV, GI.1) emerged in 1986 in Europe, rapidly spreading all over the world. Several genotypes of RHDV have been recognised over time, but in 2010, a new virus (RHDV2/RHDVb, GI.2) emerged and progressively replaced the previous RHDV strains, due to the lack of cro...
First description of a herpesvirus infection in genus Lepus
Abade dos Santos, F.A.; M. Monteiro, A. Pinto; Carvalho, C. L.; Peleteiro, Maria C.ABSTRACT - During the necropsies of Iberian hares obtained in 2018/2019, along with signs of the nodu- lar form of myxomatosis, other unexpected external lesions were also observed. Histopa- thology revealed nuclear inclusion bodies in stromal cells suggesting the additional presence of a nuclear replicating virus. Transmission electron microscopy further demon- strated the presence of herpesvirus particles in ...