3 documents found, page 1 of 1
Cinnamic acid conjugates in the rescuing and repurposing of classical antimalar...
Silva, Ana Teresa; Bento, Clara M.; Pena, Ana C.; Figueiredo, Luísa M.; Prudêncio, Cristina; Aguiar, Luísa; Silva, Tânia; Ferraz, RicardoCinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadil...
VEGF promotes malaria-associated acute lung injury in mice
Epiphanio, Sabrina; Campos, Marta G.; Pamplona, Ana; Carapau, Daniel; Pena, Ana C.; Ataíde, Ricardo; Monteiro, Carla A. A.; Félix, NunoThe spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of disease such as cerebral malaria (CM), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), pregnancy-associated malaria (PAM) or severe anemia (SA). Rodent models that mimic human CM, PAM and SA syndromes have been established. Here, we show that D...
Accumulation of Plasmodium berghei-infected red blood cells in the brain is cru...
Baptista, Fernanda G.; Pamplona, Ana; Pena, Ana C.; Mota, Maria M.; Pied, Sylviane; Vigário, Ana M.Cerebral malaria is the most severe complication of human infection with Plasmodium falciparum. It was shown that Plasmodium berghei ANKA-induced cerebral malaria was prevented in 100% of mice depleted of CD8+ T cells 1 day prior to the development of neurological signs. However, the importance of parasites in the brains of these mice was never clearly investigated. Moreover, the relevance of this model to huma...