8 documents found, page 1 of 1
Perspectives on a way forward to implementation of precision medicine in patien...
Bakker, E; Mol, PGM; Nabais, J; Vetter, T; Kezl, M; Nolan, JJ; Mayer, G; Sundgren, AK; Heerpinks, HL; Schiel, A; de Vries, ST; Gomez, MF; Schulze, FThis study aimed to identify from different stakeholders the benefits and obstacles of implementing precision medicine in diabetic kidney disease (DKD) and to build consensus about a way forward in order to treat, prevent, or even reverse this disease.Implementing precision medicine is one solution to tackle the high unmet need of new DKD treatment. A clear definition of precision medicine and its different com...
Saltquanti - development of a new portable device to analyse salt content in food
Bernardo, F; Moreira, JL; Gonçalves, C; Pena, MJ; Pinho, Olívia; Martins, R; Alves, AExcessive salt intake is a growing concern in society, impacting on a number of serious clinical conditions, such as the development of hypertension and increased mortality/morbidity caused by cardiovascular diseases. The urgent need to introduce in situ assessment of the salt content of processed foods led to the development of SALTQUANTI, a portable device developed and patented by a consortium promoted by th...
Unveiling the Metabolic Effects of Glycomacropeptide
Pena, MJ; Costa, R; Rodrigues, I; Martins, S; Guimaraes, JT; Faria, A; Calhau, C; Rocha, JC; Borges, NunoFor many years, the main nitrogen source for patients with phenylketonuria (PKU) was phenylalanine-free amino acid supplements. Recently, casein glycomacropeptide (GMP) supplements have been prescribed due to its functional and sensorial properties. Nevertheless, many doubts still persist about the metabolic effects of GMP compared to free amino acids (fAA) and intact proteins such as casein (CAS). We endeavour...
Continuous use of glycomacropeptide in the nutritional management of patients w...
Pena, MJ; Pinto, A; de Almeida, MF; Barbosa, CD; Ramos, PC; Rocha, S; Guimas, A; Ribeiro, R; Martins, E; Bandeira, A; Dias, CC; MacDonald, ABackground In phenylketonuria (PKU), modified casein glycomacropeptide supplements (CGMP-AA) are used as an alternative to the traditional phenylalanine (Phe)-free L-amino acid supplements (L-AA). However, studies focusing on the long-term nutritional status of CGMP-AA are lacking. This retrospective study evaluated the long-term impact of CGMP-AA over a mean of 29 months in 11 patients with a mean age at CGMP-...
Unveiling the Metabolic Effects of Glycomacropeptide
Pena, MJ; Costa, R; Rodrigues, I; Martins, S; Guimarães, JT; Faria, A; Calhau, C; Rocha, JC; Borges, NFor many years, the main nitrogen source for patients with phenylketonuria (PKU) was phenylalanine-free amino acid supplements. Recently, casein glycomacropeptide (GMP) supplements have been prescribed due to its functional and sensorial properties. Nevertheless, many doubts still persist about the metabolic effects of GMP compared to free amino acids (fAA) and intact proteins such as casein (CAS). We endeavour...
Acute effect of an amino acid mixture in the rat glycemic profile
Pena, MJ; Guerreiro, SG; rocha, jc; Morais, T; Pereira, SS; Monteiro, MP; Borges, NunoAmino acid mixtures (AAM) are protein substitutes used for phenylketonuria treatment, but their metabolic effects have not been well characterized. The objective of this study was to compare the acute glycemic response to free amino acids (free AA) from AAM with the response to intact protein (iProtein). Male Wistar rats (n = 14) were administered by gavage a bolus of free AA (n = 7) or iProtein as albumin (n =...
The Use of Glycomacropeptide in Patients with Phenylketonuria: A Systematic Rev...
Pena, MJ; Pinto, A; Daly, A; MacDonald, A; Azevedo L; rocha, jc; Borges, NunoIn phenylketonuria (PKU), synthetic protein derived from L-amino acids (AAs) is essential in a low-phenylalanine (Phe) diet. Glycomacropeptide (GMP), an intact protein, is very low in Phe in its native form. It has been modified and adapted for PKU to provide an alternative protein source through supplementation with rate-limiting amino acids (GMP-AAs), although it still contains residual Phe. This review aims ...
Amino acids, glucose metabolism and clinical relevance for phenylketonuria mana...
Pena, MJ; Rocha, JC; Borges, NunoIt is general knowledge that glycaemia is affected by digested nutrients. Amino acids intake appears to be an important regulator in this regard. Many questions need to be answered, such as the real mediators of this response and the mechanisms underlying this metabolic behavior. Studies have been undertaken in order to investigate the role of amino acids on metabolic parameters. Their main fndings suggest that...