11 documents found, page 1 of 2
The European Health Technology Assessment Regulation and its Potential Impact o...
Mendes, Diogo; Alves, Carlos; Penedones, Ana; Costa, Beatriz; Batel Marques, FranciscoO Regulamento (UE) 2021/2282 do Parlamento Europeu e do Conselho, de 15 de dezembro de 2021, relativo à Avaliação de Tecnologias de Saúde (ATS) será aplicado a partir de 12 de janeiro de 2025, com o objetivo de auxiliar os países da União a avaliar a efetividade relativa das novas tecnologias de saúde em processos de solicitação de financiamento por terceiras entidades pagadoras, designadamente públicas. Face à...
Performance of Aptima-HPV in the cervical cancer screening program of Portugal:...
Figueiredo, Daniel; Ribeiro, Inês; Penedones, Ana; Mendes, Diogo; Alves, Carlos; Batel-Marques, Francisco; da Silva, Daniel PereiraBackground Cervical cancer is a major concern to women’s health, being the fourth most common cancer worldwide. A great percentage of these cancer is consequence of an HPV infection, namely from specific genotypes such as 16/18. Portuguese screening program subjects women to a reflex cytology triage every 5 years. Aptima® HPV is a screening test which presents better specificity than other tests which are used ...
Performance of Aptima-HPV in the cervical cancer screening program of Portugal:...
Figueiredo, Daniel; Ribeiro, Inês; Penedones, Ana; Mendes, Diogo; Alves, Carlos; Batel-Marques, Francisco; Silva, Daniel Pereira daBackground: Cervical cancer is a major concern to women’s health, being the fourth most common cancer world‑ wide. A great percentage of these cancer is consequence of an HPV infection, namely from specifc genotypes such as 16/18. Portuguese screening program subjects women to a refex cytology triage every 5 years. Aptima® HPV is a screening test which presents better specifcity than other tests which are used ...
Rectus sheath hematoma in patients receiving subcutaneous enoxaparin: A case se...
Mendes, Diogo; Penedones, Ana; Martins, Michele; Cavadas, Susana; Alves, Carlos; Batel-Marques, FranciscoPhysicians must acknowledge the potential risk of RSH with enoxaparin. Switching home anticoagulation by enoxaparin upon hospital admission is common, but it may put patients at higher risk for RSH. Management guidelines are needed in this setting.
Recommendations to conduct and report systematic reviews in medical literature:...
Penedones, Ana; Alves, Carlos; Batel-Marques, FranciscoBackground: This scoping review aims to identify, review and characterize the published recommendations to conduct and/or to report a systematic review in medical interventions area. Methods: A search was carried out in PubMed, EMBASE and Cochrane Library databases, using systematic reviews search filters. The search comprises all recommendations to conduct and/or report a systematic review. Data on methods wer...
Effectiveness in clinical practice versus efficacy of dipeptidyl peptidase-4 in...
Batel-Marques, Francisco; Pereira, Diogo; Mendes, Diogo; Alves, Carlos; Penedones, AnaData supporting the use of oral antidiabetic drugs mainly rely on data from premarketing clinical trials. Real-world data studies are crucial to evaluate effectiveness of drugs. The aim of this systematic review is to compare the results obtained for efficacy and effectiveness endpoints on clinical trials and those obtained from routine clinical practice of dipeptidyl peptidase-4 inhibitors. Methods and analysi...
A comparison between two recommendations to conduct and report systematic revie...
Penedones, Ana; Alves, Carlos; Batel-Marques, FranciscoBackground: Several recommendations are available to conduct and report a systematic review of adverse drug reactions. This study is aimed at identifying and comparing the methodologies of the two most commonly used recommendations to conduct and report systematic reviews on drug’s safety. Methods: Two systematic reviews were conducted following the recommendations “Cochrane Handbook for Systematic Reviews of I...
A systematic review of observational studies evaluating costs of adverse drug r...
Batel-Marques, Francisco; Penedones, Ana; Mendes, Diogo; Alves, CarlosIntroduction: The growing evidence of the increased frequency and severity of adverse drug events (ADEs), besides the negative impact on patient’s health status, indicates that costs due to ADEs may be steadily rising. Observational studies are an important tool in pharmacovigilance. Despite these studies being more susceptible to bias than experimental designs, they are more competent in assessing ADEs and the...
SAFETY OF OPHTHALMIC BIOLOGICS: A SYSTEMATIC REVIEW
Penedones, Ana; Mendes, Diogo; Alves, Carlos; Batel Marques, FranciscoObjectives: The present study evaluates the safety of ophthalmic biologics.Methods: The website of European Medicines Agency was searched in order to identify the biologics with approved therapeutic indications in ophthalmology. MEDLINE, Cochrane Library and ClinicalTrials.gov databases were searched systematically, up to October 2014. The study was divided in two settings: pre- and postmarketing. Phase III and...
Farmacovigilância em Portugal: Atividade da Unidade Regional do Centro
Batel-Marques, Francisco; Mendes, Diogo; Alves, Carlos; Penedones, Ana; Dias, Patrícia; Martins, Angelina; Santiago, Luiz MiguelIntrodução: Caracterizar as notificações espontâneas de eventos adversos a medicamentos recebidas pela Unidade de Farmacovigilância do Centro. Material e Métodos: Consideraram-se todas as notificações reportadas entre 01/2001 e 12/2013. Estimaram-se taxas de notificação anuais. Os casos foram caracterizados quanto à gravidade, conhecimento prévio, causalidade imputada, origem e grupo profissional do notificador...